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Label-free biosensing characteristics of micro/nano-fiber coupler
Wang, H.; W. Zhou; K. Li; P. Hao; M. Chi and Y. Wu
Source PublicationGuangxue Xuebao/Acta Optica Sinica
AbstractA portable biosensor with high sensitivity is proposed, and the biosensor is based on a micro/nano-fiber coupler. When the biosensor is used in label-free biodetection, its sensitivity and reusability are studied. A fiber coupler with the waist diameter of 3 m is fabricated by the fused biconical taper method, and then the coupler is used in refractive index detection experiment. A refractive index sensitivity of 1402.3 nm/RIU is measured in experiment. The detection results are fitted, and the correlation coefficient of the fitted curve is 0.99459.The calculated results of the weak coupling model of the micro/nano-fiber coupler are in good agreement with the experimental results. The detection limit of 2 pg/mL is obtained when the micro/nano-fiber coupler is used to detect goat immune globulin (IgG) antigen. The reusability of the biosensor is verified by 10 dissociation experiments. These experiments demonstrate that the micro/nano-fiber coupler can obtain a high detection sensitivity in the label-free biosensing and has good practical value. 2017, Chinese Lasers Press. All right reserved.
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Document Type期刊论文
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GB/T 7714
Wang, H.,W. Zhou,K. Li,et al. Label-free biosensing characteristics of micro/nano-fiber coupler[J]. Guangxue Xuebao/Acta Optica Sinica,2017,37(3).
APA Wang, H.,W. Zhou,K. Li,P. Hao,&M. Chi and Y. Wu.(2017).Label-free biosensing characteristics of micro/nano-fiber coupler.Guangxue Xuebao/Acta Optica Sinica,37(3).
MLA Wang, H.,et al."Label-free biosensing characteristics of micro/nano-fiber coupler".Guangxue Xuebao/Acta Optica Sinica 37.3(2017).
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