Unraveling an Innate Mechanism of Pathological Mineralization-Regulated Inflammation by a Nanobiomimetic System

doi:10.1002/adhm.202101586

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	Unraveling an Innate Mechanism of Pathological Mineralization-Regulated Inflammation by a Nanobiomimetic System
	D. Wang; X. Wang; L. Huang; Z. Pan; K. Liu; B. Du; Y. Xue; B. Li; Y. Zhang; H. Wang; D. Li and H. Sun
	2021
发表期刊	Advanced Healthcare Materials
ISSN	21922640
卷号	10 期号:23
摘要	Pathological mineralization (PTM) often occurs under inflammation and affects the prognosis of diseases, such as atherosclerosis and cancers. However, how the PTM impacts inflammation has not been well explored. Herein, poly lactic-co-glycolic acid (PLGA)/gelatin/hydroxyapatite (HA) electrospun nanofibers are rationally designed as an ideal PTM microenvironment biomimetic system for unraveling the role of PTM on inflammation. The results demonstrate that the inflammatory response decreases continuously during the process of mineralization. When mature macromineralization forms, the inflammation almost completely disappears. Mechanistically, the PTM formation is mediated by matrix proteins, local high calcium, and cell debris (nuclei), or actively regulated by the lysosomal/plasma membrane components secreted by macrophages. These inflammatory inducible factors (calcium, cell debris, etc.) can be "buried" through PTM process, resulting in reduced immune responses. Overall, the present study demonstrates that PTM is an innate mechanism of inflammation subsidence, providing valuable insight into understanding the action of mineralization on inflammation. 2021 Wiley-VCH GmbH
DOI	10.1002/adhm.202101586
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收录类别	SCI ; EI
引用统计
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/65735
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	D. Wang,X. Wang,L. Huang,et al. Unraveling an Innate Mechanism of Pathological Mineralization-Regulated Inflammation by a Nanobiomimetic System[J]. Advanced Healthcare Materials,2021,10(23).
APA	D. Wang.,X. Wang.,L. Huang.,Z. Pan.,K. Liu.,...&D. Li and H. Sun.(2021).Unraveling an Innate Mechanism of Pathological Mineralization-Regulated Inflammation by a Nanobiomimetic System.Advanced Healthcare Materials,10(23).
MLA	D. Wang,et al."Unraveling an Innate Mechanism of Pathological Mineralization-Regulated Inflammation by a Nanobiomimetic System".Advanced Healthcare Materials 10.23(2021).

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