A scintillating nanoplatform with upconversion function for the synergy of radiation and photodynamic therapies for deep tumors

doi:10.1039/d1tc04930e

CIOMP OpenIR

	A scintillating nanoplatform with upconversion function for the synergy of radiation and photodynamic therapies for deep tumors
	Y. S. Feng; X. M. Liu; Q. Q. Li; S. L. Mei; K. F. Wu; J. Yuan; L. P. Tu; I. Que; F. Tamburini; F. Baldazzi; A. Chan; L. J. Cruz; J. Zuo; C. J. Yao and H. Zhang
	2022
Source Publication	Journal of Materials Chemistry C
ISSN	2050-7526
Volume	10 Issue:2 Pages:688-695
Abstract	Collaborative therapy is regarded as an effective approach in increasing the therapeutic efficacy of cancer. In this work, we have proposed and validated the concept of upconversion lumienscence image guided synergy of photodynamic therapy (PDT) and radiotherapy (RT) for deep cancer, via a specially designed nanoplatform integrating near infrared (NIR) light activated luminescence upconversion and X-ray induced scintillation. Upon NIR light irradiation, the nanoplatform emits highly monochromatic red light solely for imaging the targeted cancer cells without triggering therapy; however, when the irradiation turns to a low dose of X-rays, scintillation will occur which induces effectively the PDT destroying the cancer cells together with X-ray induced RT. The novel theranostic nanoplatform is constructed in such a way that the interactions between the upconversion core and the outmost scintillating shell are blocked effectively by an inert layer between them. This structural design not only enables a nearly perfect excitation energy delivery (similar to 100% at a spectral overlapping wavelength of similar to 540 nm) from the outermost scintellating layer to the surface-anchored photosensitizers and so a maximum yield of radical oxygen species, but also achieves a strong NIR induced upconversion luminescence for imaging. Since PDT and RT attack different parts of a cancer cell, this synergy is more effective in destroying cancer than a single therapy, resulting in the reduction of the X-ray irradiation dosage. As a proof of principle, the theranostic effect is validated by in vitro and in vivo experiments, exhibiting the great potential of this sort of nanoplatform in deep cancer treatment.
DOI	10.1039/d1tc04930e
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Indexed By	SCI
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Document Type	期刊论文
Identifier	http://ir.ciomp.ac.cn/handle/181722/65613
Collection	中国科学院长春光学精密机械与物理研究所
Recommended Citation GB/T 7714	Y. S. Feng,X. M. Liu,Q. Q. Li,et al. A scintillating nanoplatform with upconversion function for the synergy of radiation and photodynamic therapies for deep tumors[J]. Journal of Materials Chemistry C,2022,10(2):688-695.
APA	Y. S. Feng.,X. M. Liu.,Q. Q. Li.,S. L. Mei.,K. F. Wu.,...&C. J. Yao and H. Zhang.(2022).A scintillating nanoplatform with upconversion function for the synergy of radiation and photodynamic therapies for deep tumors.Journal of Materials Chemistry C,10(2),688-695.
MLA	Y. S. Feng,et al."A scintillating nanoplatform with upconversion function for the synergy of radiation and photodynamic therapies for deep tumors".Journal of Materials Chemistry C 10.2(2022):688-695.

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中国科学院长春光学精密机械与物理研究所