CIOMP OpenIR
A scintillating nanoplatform with upconversion function for the synergy of radiation and photodynamic therapies for deep tumors
Y. S. Feng; X. M. Liu; Q. Q. Li; S. L. Mei; K. F. Wu; J. Yuan; L. P. Tu; I. Que; F. Tamburini; F. Baldazzi; A. Chan; L. J. Cruz; J. Zuo; C. J. Yao and H. Zhang
2022
Source PublicationJournal of Materials Chemistry C
ISSN2050-7526
Volume10Issue:2Pages:688-695
AbstractCollaborative therapy is regarded as an effective approach in increasing the therapeutic efficacy of cancer. In this work, we have proposed and validated the concept of upconversion lumienscence image guided synergy of photodynamic therapy (PDT) and radiotherapy (RT) for deep cancer, via a specially designed nanoplatform integrating near infrared (NIR) light activated luminescence upconversion and X-ray induced scintillation. Upon NIR light irradiation, the nanoplatform emits highly monochromatic red light solely for imaging the targeted cancer cells without triggering therapy; however, when the irradiation turns to a low dose of X-rays, scintillation will occur which induces effectively the PDT destroying the cancer cells together with X-ray induced RT. The novel theranostic nanoplatform is constructed in such a way that the interactions between the upconversion core and the outmost scintillating shell are blocked effectively by an inert layer between them. This structural design not only enables a nearly perfect excitation energy delivery (similar to 100% at a spectral overlapping wavelength of similar to 540 nm) from the outermost scintellating layer to the surface-anchored photosensitizers and so a maximum yield of radical oxygen species, but also achieves a strong NIR induced upconversion luminescence for imaging. Since PDT and RT attack different parts of a cancer cell, this synergy is more effective in destroying cancer than a single therapy, resulting in the reduction of the X-ray irradiation dosage. As a proof of principle, the theranostic effect is validated by in vitro and in vivo experiments, exhibiting the great potential of this sort of nanoplatform in deep cancer treatment.
DOI10.1039/d1tc04930e
URL查看原文
Indexed BySCI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ciomp.ac.cn/handle/181722/65613
Collection中国科学院长春光学精密机械与物理研究所
Recommended Citation
GB/T 7714
Y. S. Feng,X. M. Liu,Q. Q. Li,et al. A scintillating nanoplatform with upconversion function for the synergy of radiation and photodynamic therapies for deep tumors[J]. Journal of Materials Chemistry C,2022,10(2):688-695.
APA Y. S. Feng.,X. M. Liu.,Q. Q. Li.,S. L. Mei.,K. F. Wu.,...&C. J. Yao and H. Zhang.(2022).A scintillating nanoplatform with upconversion function for the synergy of radiation and photodynamic therapies for deep tumors.Journal of Materials Chemistry C,10(2),688-695.
MLA Y. S. Feng,et al."A scintillating nanoplatform with upconversion function for the synergy of radiation and photodynamic therapies for deep tumors".Journal of Materials Chemistry C 10.2(2022):688-695.
Files in This Item: Download All
File Name/Size DocType Version Access License
A scintillating nano(5628KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Y. S. Feng]'s Articles
[X. M. Liu]'s Articles
[Q. Q. Li]'s Articles
Baidu academic
Similar articles in Baidu academic
[Y. S. Feng]'s Articles
[X. M. Liu]'s Articles
[Q. Q. Li]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Y. S. Feng]'s Articles
[X. M. Liu]'s Articles
[Q. Q. Li]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: A scintillating nanoplatform with upconversion.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.