Design of a bi-functional NaScF4: Yb3+/Er3+ nanoparticles for deep-tissue bioimaging and optical thermometry through Mn2+ doping

doi:10.1016/j.talanta.2020.121832

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	Design of a bi-functional NaScF4: Yb3+/Er3+ nanoparticles for deep-tissue bioimaging and optical thermometry through Mn2+ doping
	G. Xiang; X. Liu; Q. Xia; X. Liu; S. Xu; S. Jiang; X. Zhou; L. Li; D. Wu; L. Ma; X. Wang and J. Zhang
	2021
发表期刊	Talanta
ISSN	399140
卷号	224
摘要	An approximately monochromatic red upconversion (UC) emission is successfully realized in NaScF4: Yb3+/Er3+ nanoparticles (NPs) through Mn2+ ions doping without phase transition. The Mn2+ ions play a role of bridge during the energy transfer process from green emission state 2H11/2/4S3/2 of Er3+ to red emission state 4F9/2 of Er3+, which significantly accelerates the red UC enhancement. The strongest red luminescence is observed in the sample containing 10% Mn2+ ions (Mn-10) with an enhancement factor of 7.5 times. Meanwhile, an ultrasensitive optical thermometry in the physiological temperature region can be realized by utilizing the fluorescence intensity ratio (FIR) between two thermally coupled Stark transitions of Er3+: 4I13/2 4I15/2, locating in the near-infrared (NIR) long wavelength region of the second biological window. Its relative sensitivity SR can be expressed by 340/T2, which is much higher than most optical thermometers based on thermally coupled Stark sublevels reported by the previous papers. Beyond that, an ex vivo experiment is designed to evaluate the penetration depth of the red and NIR emission of Mn-10 in the biological tissues, revealing that they can reach depth of at least 3 mm and 5 mm respectively. More importantly, the increasing tissue thickness has almost no effect on the FIR values. All the results show that the present sample is a promising bi-functional nano probe which can be used for bioimaging and temperature sensing in the deep tissues through the strong red UC emission and ultrasensitive NIR optical thermometer, respectively. 2020 Elsevier B.V.
DOI	10.1016/j.talanta.2020.121832
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收录类别	SCI ; EI
引用统计
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/65151
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	G. Xiang,X. Liu,Q. Xia,et al. Design of a bi-functional NaScF4: Yb3+/Er3+ nanoparticles for deep-tissue bioimaging and optical thermometry through Mn2+ doping[J]. Talanta,2021,224.
APA	G. Xiang.,X. Liu.,Q. Xia.,X. Liu.,S. Xu.,...&X. Wang and J. Zhang.(2021).Design of a bi-functional NaScF4: Yb3+/Er3+ nanoparticles for deep-tissue bioimaging and optical thermometry through Mn2+ doping.Talanta,224.
MLA	G. Xiang,et al."Design of a bi-functional NaScF4: Yb3+/Er3+ nanoparticles for deep-tissue bioimaging and optical thermometry through Mn2+ doping".Talanta 224(2021).

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