Succinyl rotundic acid inhibits growth and promotes apoptosis in the HeLa cervical cancer cell line

doi:10.1166/mex.2020.1660

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	Succinyl rotundic acid inhibits growth and promotes apoptosis in the HeLa cervical cancer cell line
	Y. F. He,J. M. Sun,M. L. Nang,X. Wang,H. Lin,G. F. Lv,Y. Li,M. H. Duan and H. B. Ye
	2020
发表期刊	Materials Express
ISSN	2158-5849
卷号	10 期号:4 页码:571-577
摘要	Rotundic acid (RA) is a kind of pentacyclic triterpene saponins, which widely exists in holly and other plants. It has anti-tumor and lipid-lowering effects, and has been widely used in the prevention and treatment of vascular diseases. Succinyl RA (SRA) is a kind of circular acid derivative with strong water solubility. However, SRA's effect and mechanism about the therapy of cervical cancer is still not clarified. The inhibitory effect of SRA on Hela cells and its molecular mechanism were investigated in this study. Hela cell line was used to establish an in vitro model to study the effect of SRA. The effects of SRA on cell proliferation, cell cycle and apoptosis were analyzed by flow cytometry and detected by 3-(4,5-dimethyl thiazole-2-yl)-2, 5-diphenyltetrazole bromide. The experimental results show that SRA can inhibit the growth of Hela and diffusion, inducing cell apoptosis. SRA can also reduce the expression of CyclinD 1 and p21. It was also decreased the expression of apoptosis inhibitor B cell lymphoma (Bcl-2), and increased the expression of Bcl-2-related X-protein and Caspase-3. This study provides evidence for the progress of SRA in inhibiting Hela cells and presents potential applications of SRA as an alternative therapy for cervical cancer.
DOI	10.1166/mex.2020.1660
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收录类别	SCI
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/64927
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	Y. F. He,J. M. Sun,M. L. Nang,X. Wang,H. Lin,G. F. Lv,Y. Li,M. H. Duan and H. B. Ye. Succinyl rotundic acid inhibits growth and promotes apoptosis in the HeLa cervical cancer cell line[J]. Materials Express,2020,10(4):571-577.
APA	Y. F. He,J. M. Sun,M. L. Nang,X. Wang,H. Lin,G. F. Lv,Y. Li,M. H. Duan and H. B. Ye.(2020).Succinyl rotundic acid inhibits growth and promotes apoptosis in the HeLa cervical cancer cell line.Materials Express,10(4),571-577.
MLA	Y. F. He,J. M. Sun,M. L. Nang,X. Wang,H. Lin,G. F. Lv,Y. Li,M. H. Duan and H. B. Ye."Succinyl rotundic acid inhibits growth and promotes apoptosis in the HeLa cervical cancer cell line".Materials Express 10.4(2020):571-577.

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