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Succinyl rotundic acid inhibits growth and promotes apoptosis in the HeLa cervical cancer cell line
Y. F. He,J. M. Sun,M. L. Nang,X. Wang,H. Lin,G. F. Lv,Y. Li,M. H. Duan and H. B. Ye
2020
发表期刊Materials Express
ISSN2158-5849
卷号10期号:4页码:571-577
摘要Rotundic acid (RA) is a kind of pentacyclic triterpene saponins, which widely exists in holly and other plants. It has anti-tumor and lipid-lowering effects, and has been widely used in the prevention and treatment of vascular diseases. Succinyl RA (SRA) is a kind of circular acid derivative with strong water solubility. However, SRA's effect and mechanism about the therapy of cervical cancer is still not clarified. The inhibitory effect of SRA on Hela cells and its molecular mechanism were investigated in this study. Hela cell line was used to establish an in vitro model to study the effect of SRA. The effects of SRA on cell proliferation, cell cycle and apoptosis were analyzed by flow cytometry and detected by 3-(4,5-dimethyl thiazole-2-yl)-2, 5-diphenyltetrazole bromide. The experimental results show that SRA can inhibit the growth of Hela and diffusion, inducing cell apoptosis. SRA can also reduce the expression of CyclinD 1 and p21. It was also decreased the expression of apoptosis inhibitor B cell lymphoma (Bcl-2), and increased the expression of Bcl-2-related X-protein and Caspase-3. This study provides evidence for the progress of SRA in inhibiting Hela cells and presents potential applications of SRA as an alternative therapy for cervical cancer.
DOI10.1166/mex.2020.1660
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收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.ciomp.ac.cn/handle/181722/64927
专题中国科学院长春光学精密机械与物理研究所
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Y. F. He,J. M. Sun,M. L. Nang,X. Wang,H. Lin,G. F. Lv,Y. Li,M. H. Duan and H. B. Ye. Succinyl rotundic acid inhibits growth and promotes apoptosis in the HeLa cervical cancer cell line[J]. Materials Express,2020,10(4):571-577.
APA Y. F. He,J. M. Sun,M. L. Nang,X. Wang,H. Lin,G. F. Lv,Y. Li,M. H. Duan and H. B. Ye.(2020).Succinyl rotundic acid inhibits growth and promotes apoptosis in the HeLa cervical cancer cell line.Materials Express,10(4),571-577.
MLA Y. F. He,J. M. Sun,M. L. Nang,X. Wang,H. Lin,G. F. Lv,Y. Li,M. H. Duan and H. B. Ye."Succinyl rotundic acid inhibits growth and promotes apoptosis in the HeLa cervical cancer cell line".Materials Express 10.4(2020):571-577.
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