In vivo theranostics with near-infrared-emitting carbon dots-highly efficient photothermal therapy based on passive targeting after intravenous administration

doi:10.1038/s41377-018-0090-1

CIOMP OpenIR

	In vivo theranostics with near-infrared-emitting carbon dots-highly efficient photothermal therapy based on passive targeting after intravenous administration
	Bao, Xin 1,2; Yuan, Ye3 ; Chen, Jingqin 4; Zhang, Bohan 1,2; Li, Di 1; Zhou, Ding 1; Jing, Pengtao1 ; Xu, Guiying 5; Wang, Yingli 5; Hola, Katerina 6; Shen, Dezhen1 ; Wu, Changfeng 3; Song, Liang 4,7; Liu, Chengbo 4; Zboril, Radek 6; Qu, Songnan1
	2018-11-21
发表期刊	LIGHT-SCIENCE & APPLICATIONS
ISSN	2047-7538
卷号	7 页码:11
通讯作者	Liu, Chengbo(cb.liu@siat.ac.cn) ; Zboril, Radek(radek.zboril@upol.cz) ; Qu, Songnan(qusn@ciomp.ac.cn)
摘要	Carbon dots that exhibit near-infrared fluorescence (NIR CDs) are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents. Despite progress in the synthesis of NIR CDs, there remains a key obstacle to using them as an in vivo theranostic agent. This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy (PTT) in mouse models (conversion efficiency of 59%) and can be readily visualized by photoluminescence and photoacoustic imaging. The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting. Contrary to all other nanomaterials that have been tested in biomedicine, they are excreted through the body's renal filtration system. Moreover, after intravenous injection, NIR CDs are accumulated in tumor tissue via passive targeting, without any active species such as antibodies. Due to their accumulation in tumor tissue without the need for intratumor injection, high photothermal conversion, excel lent optical and photoacoustic imaging performance, and renal excretion, the developed CDs are suitable for transfer to clinical biomedical practice.
关键词	semiconducting polymer nanoparticles graphene quantum dots nanodots synthesis tumor uptake fluorescent cells agent photocatalysts nanospheres oxide Optics
DOI	10.1038/s41377-018-0090-1
关键词[WOS]	SEMICONDUCTING POLYMER NANOPARTICLES ; GRAPHENE QUANTUM DOTS ; CANCER-THERAPY ; SUPRA-(CARBON NANODOTS) ; 2-PHOTON FLUORESCENCE ; TUMOR UPTAKE ; LIVING MICE ; CELLS ; AGENT ; PHOTOCATALYSTS
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[51602304] ; National Natural Science Foundation of China[91739117] ; National Natural Science Foundation of China[81527024] ; National Natural Science Foundation of China[61335001] ; National Natural Science Foundation of China[81771930] ; Youth Innovation Promotion Association of CAS ; Jilin Province Science and Technology Research[20170101191JC] ; Jilin Province Science and Technology Research[20170101042JC] ; Jilin Province Science and Technology Research[20160520008JH] ; Jilin Province Science and Technology Research[20150519003JH] ; Shenzhen Science and Technology Innovation Commission[JCYJ20170307110157501] ; Operational Proqramme Research, Development and Education-European Re qional Development Fund of the Ministry of Education, Youth and Sports of the Czech Republic[CZ. 02. 1. 01/0.0/0.0/16-019/0000754] ; Ministry of Education, Youth
项目资助者	National Natural Science Foundation of China ; Youth Innovation Promotion Association of CAS ; Jilin Province Science and Technology Research ; Shenzhen Science and Technology Innovation Commission ; Operational Proqramme Research, Development and Education-European Re qional Development Fund of the Ministry of Education, Youth and Sports of the Czech Republic ; Ministry of Education, Youth
WOS研究方向	Optics
WOS类目	Optics
WOS记录号	WOS:000450708600002
出版者	CHINESE ACAD SCIENCES, CHANGCHUN INST OPTICS FINE MECHANICS AND PHYSICS
引用统计
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/60283
专题	中国科学院长春光学精密机械与物理研究所
通讯作者	Liu, Chengbo; Zboril, Radek; Qu, Songnan
作者单位	1.Chinese Acad Sci, Changchun Inst Opt Fine Mech & Phys, State Key Lab Luminescence & Applicat, 3888 Dong Nanhu Rd, Changchun 130033, Jilin, Peoples R China 2.Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100190, Peoples R China 3.Southern Univ Sci & Engn, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China 4.Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Hlth Engn, Res Lab Biomed Opt & Mol Imaging, Shenzhen 518055, Peoples R China 5.Jilin Prov Tumor Hosp, Changchun, Jilin, Peoples R China 6.Palacky Univ Olomouc, Dept Phys Chem, Reg Ctr Adv Technol & Mat, Fac Sci, Olomouc 78371, Czech Republic 7.Shenzhen Inst Adv Technol, CAS Key Lab Hlth Informat, Shenzhen 518055, Peoples R China
推荐引用方式 GB/T 7714	Bao, Xin,Yuan, Ye,Chen, Jingqin,et al. In vivo theranostics with near-infrared-emitting carbon dots-highly efficient photothermal therapy based on passive targeting after intravenous administration[J]. LIGHT-SCIENCE & APPLICATIONS,2018,7:11.
APA	Bao, Xin.,Yuan, Ye.,Chen, Jingqin.,Zhang, Bohan.,Li, Di.,...&Qu, Songnan.(2018).In vivo theranostics with near-infrared-emitting carbon dots-highly efficient photothermal therapy based on passive targeting after intravenous administration.LIGHT-SCIENCE & APPLICATIONS,7,11.
MLA	Bao, Xin,et al."In vivo theranostics with near-infrared-emitting carbon dots-highly efficient photothermal therapy based on passive targeting after intravenous administration".LIGHT-SCIENCE & APPLICATIONS 7(2018):11.

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