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Role of S100A3 in human hepatocellular carcinoma and the anticancer effect of sodium cantharidinate
Tao, R.; Z. F. Wang; W. Qiu; Y. F. He; W. Q. Yan; W. Y. Sun and H. J. Li
2017
Source PublicationExperimental and Therapeutic Medicine
Volume13Issue:6
AbstractThe fifth most common cancer worldwide is hepatocellular carcinoma (HCC), which has an annual mortality rate of similar to 800,000. Although surgical procedures for HCC, such as hepatic resection and liver transplantation, have progressed and the outcomes of patients have improved, HCC is still characterized by frequent recurrence, even after liver transplantation. In the present study the expression of the protein coding gene, S100 calcium binding protein A3 (S100A3), was observed in 62 HCC tissues and tumor-surrounding tissues. The present study indicated that S100A3 activation was involved in tumorigenesis and tumor aggressiveness. The protein and mRNA expression levels of S100A3 in the human HCC cell line (HepG2) were investigated using western blotting and reverse transcription-quantitative polymerase chain reaction analysis, respectively. The function of sodium cantharidinate in inducing HCC cell apoptosis was also investigated. Sodium cantharidinate inhibited the protein and gene expression of S100A3 in HepG2 cells in vitro. These data suggested that S100A3 has an important role in human HCC. The present study indicates that the functional properties of sodium cantharidinate are promising for the development of a novel drug that may control the expression of S100A3 and improve the treatment of human HCC in the near future.
Indexed Bysci ; ei
Language英语
Document Type期刊论文
Identifierhttp://ir.ciomp.ac.cn/handle/181722/59218
Collection中科院长春光机所知识产出
Recommended Citation
GB/T 7714
Tao, R.,Z. F. Wang,W. Qiu,et al. Role of S100A3 in human hepatocellular carcinoma and the anticancer effect of sodium cantharidinate[J]. Experimental and Therapeutic Medicine,2017,13(6).
APA Tao, R.,Z. F. Wang,W. Qiu,Y. F. He,W. Q. Yan,&W. Y. Sun and H. J. Li.(2017).Role of S100A3 in human hepatocellular carcinoma and the anticancer effect of sodium cantharidinate.Experimental and Therapeutic Medicine,13(6).
MLA Tao, R.,et al."Role of S100A3 in human hepatocellular carcinoma and the anticancer effect of sodium cantharidinate".Experimental and Therapeutic Medicine 13.6(2017).
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