CIOMP OpenIR  > 中科院长春光机所知识产出
Amphiphilic copolymer and TPGS mixed magnetic hybrid micelles for stepwise targeted co-delivery of DOX/TPP-DOX and image-guided chemotherapy with enhanced antitumor activity in liver cancer
Shi, X. J.; G. Y. Lv; X. D. Sun; D. B. Cao; G. Y. Wang and Y. L. Chang
2017
Source PublicationRsc Advances
Volume7Issue:41
AbstractRecently, several targeted drug delivery systems have shown promising antitumor activity towards different types of cancer. However, targeting the tumor microenvironment, cellular surface and/or only one organelle may not achieve the expected therapeutic effects. Herein, a targeted drug delivery with stepwise targeting and image-guided strategy was obtained for enhancing antitumor therapy and overcoming various problems caused by the random drug distribution of traditional medicine. In this design, a multifunctional nanoplatform, TPGS/PPG2L@ IONPs@ DOX/TPP-DOX, based on poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(amidoamine)-lactose acid (mPEG-PCL-G2.0 PAMAM-LA, PPG2L) copolymer and D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS), as a co-carrier, incorporates iron oxide nanoparticles (IONPs) as imaging agents and loads a DOX/triphenylphosphonium (TPP)-DOX drug for chemotherapy. In this nanoplatform micelle, the LA as targeting moieties to hepatocarcinoma cells is the first targeting step. After the drug is released from the hybrid micelles, the incorporated DOX and TPP-DOX target delivery to nuclei and mitochondria for the next targeting step. Furthermore, with the help of MRI contrast agents of IONPs, the distribution of hybrid micelles was monitored. As a result, the hybrid micelles demonstrated enhanced antitumor cell activity in both HepG2 and HepG2/DOX cells. The results indicated that the multifunctional hybrid micelles showed great potential in enhancing antitumor activity under image-guided and stepwise targeted chemotherapy.
Indexed Bysci ; ei
Language英语
Document Type期刊论文
Identifierhttp://ir.ciomp.ac.cn/handle/181722/59186
Collection中科院长春光机所知识产出
Recommended Citation
GB/T 7714
Shi, X. J.,G. Y. Lv,X. D. Sun,et al. Amphiphilic copolymer and TPGS mixed magnetic hybrid micelles for stepwise targeted co-delivery of DOX/TPP-DOX and image-guided chemotherapy with enhanced antitumor activity in liver cancer[J]. Rsc Advances,2017,7(41).
APA Shi, X. J.,G. Y. Lv,X. D. Sun,D. B. Cao,&G. Y. Wang and Y. L. Chang.(2017).Amphiphilic copolymer and TPGS mixed magnetic hybrid micelles for stepwise targeted co-delivery of DOX/TPP-DOX and image-guided chemotherapy with enhanced antitumor activity in liver cancer.Rsc Advances,7(41).
MLA Shi, X. J.,et al."Amphiphilic copolymer and TPGS mixed magnetic hybrid micelles for stepwise targeted co-delivery of DOX/TPP-DOX and image-guided chemotherapy with enhanced antitumor activity in liver cancer".Rsc Advances 7.41(2017).
Files in This Item: Download All
File Name/Size DocType Version Access License
Amphiphilic copolyme(1340KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Shi, X. J.]'s Articles
[G. Y. Lv]'s Articles
[X. D. Sun]'s Articles
Baidu academic
Similar articles in Baidu academic
[Shi, X. J.]'s Articles
[G. Y. Lv]'s Articles
[X. D. Sun]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Shi, X. J.]'s Articles
[G. Y. Lv]'s Articles
[X. D. Sun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Amphiphilic copolymer.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.