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Amphiphilic copolymer and TPGS mixed magnetic hybrid micelles for stepwise targeted co-delivery of DOX/TPP-DOX and image-guided chemotherapy with enhanced antitumor activity in liver cancer
Shi, X. J.; G. Y. Lv; X. D. Sun; D. B. Cao; G. Y. Wang and Y. L. Chang
2017
发表期刊Rsc Advances
卷号7期号:41
摘要Recently, several targeted drug delivery systems have shown promising antitumor activity towards different types of cancer. However, targeting the tumor microenvironment, cellular surface and/or only one organelle may not achieve the expected therapeutic effects. Herein, a targeted drug delivery with stepwise targeting and image-guided strategy was obtained for enhancing antitumor therapy and overcoming various problems caused by the random drug distribution of traditional medicine. In this design, a multifunctional nanoplatform, TPGS/PPG2L@ IONPs@ DOX/TPP-DOX, based on poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(amidoamine)-lactose acid (mPEG-PCL-G2.0 PAMAM-LA, PPG2L) copolymer and D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS), as a co-carrier, incorporates iron oxide nanoparticles (IONPs) as imaging agents and loads a DOX/triphenylphosphonium (TPP)-DOX drug for chemotherapy. In this nanoplatform micelle, the LA as targeting moieties to hepatocarcinoma cells is the first targeting step. After the drug is released from the hybrid micelles, the incorporated DOX and TPP-DOX target delivery to nuclei and mitochondria for the next targeting step. Furthermore, with the help of MRI contrast agents of IONPs, the distribution of hybrid micelles was monitored. As a result, the hybrid micelles demonstrated enhanced antitumor cell activity in both HepG2 and HepG2/DOX cells. The results indicated that the multifunctional hybrid micelles showed great potential in enhancing antitumor activity under image-guided and stepwise targeted chemotherapy.
收录类别sci ; ei
语种英语
文献类型期刊论文
条目标识符http://ir.ciomp.ac.cn/handle/181722/59186
专题中科院长春光机所知识产出
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Shi, X. J.,G. Y. Lv,X. D. Sun,et al. Amphiphilic copolymer and TPGS mixed magnetic hybrid micelles for stepwise targeted co-delivery of DOX/TPP-DOX and image-guided chemotherapy with enhanced antitumor activity in liver cancer[J]. Rsc Advances,2017,7(41).
APA Shi, X. J.,G. Y. Lv,X. D. Sun,D. B. Cao,&G. Y. Wang and Y. L. Chang.(2017).Amphiphilic copolymer and TPGS mixed magnetic hybrid micelles for stepwise targeted co-delivery of DOX/TPP-DOX and image-guided chemotherapy with enhanced antitumor activity in liver cancer.Rsc Advances,7(41).
MLA Shi, X. J.,et al."Amphiphilic copolymer and TPGS mixed magnetic hybrid micelles for stepwise targeted co-delivery of DOX/TPP-DOX and image-guided chemotherapy with enhanced antitumor activity in liver cancer".Rsc Advances 7.41(2017).
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