Self-Targeting Fluorescent Carbon Dots for Diagnosis of Brain Cancer Cells

	Self-Targeting Fluorescent Carbon Dots for Diagnosis of Brain Cancer Cells
	Zheng, M.; S. B. Ruan; S. Liu; T. T. Sun; D. Qu; H. F. Zhao; Z. G. Xie; H. L. Gao; X. B. Jing and Z. C. Sun
	2015
发表期刊	Acs Nano
卷号	9 期号:11 页码:11455-11461
摘要	A new type of carbon dots (CD-Asp) with targeting function toward brain cancer glioma was synthesized via a straightforward pyrolysis route by using a-glucose and L-aspartic acid as starting materials. The as-prepared CD-Asp exhibits not only excellent biocompatibility and tunable full-color emission, but also significant capability of targeting C6 glioma cells without the aid of any extra targeting molecules. In vivo fluorescence images showed high-contrast biodistribution of CD-Asp 15 min after tail vein injection. A much stronger fluorescent signal was detected in the glioma site than that in normal brain, indicating their ability to freely penetrate the blood brain barrier and precisely targeting glioma tissue. However, its counterparts, the CDs synthesized from a-glucose (CD-G), L-asparic acid (CD-A), or D-glucose and L-glutannic acid (CD-Glu) have no or low selectivity for glioma. Therefore, CD-Asp could act as a fluorescence imaging and targeting agent for noninvasive glioma diagnosis. This work highlights the potential application of CDs for constructing an intelligent nanomedicine with integration of diagnostic, targeting, and therapeutic functions.
收录类别	SCI ; EI
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/55535
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	Zheng, M.,S. B. Ruan,S. Liu,et al. Self-Targeting Fluorescent Carbon Dots for Diagnosis of Brain Cancer Cells[J]. Acs Nano,2015,9(11):11455-11461.
APA	Zheng, M..,S. B. Ruan.,S. Liu.,T. T. Sun.,D. Qu.,...&X. B. Jing and Z. C. Sun.(2015).Self-Targeting Fluorescent Carbon Dots for Diagnosis of Brain Cancer Cells.Acs Nano,9(11),11455-11461.
MLA	Zheng, M.,et al."Self-Targeting Fluorescent Carbon Dots for Diagnosis of Brain Cancer Cells".Acs Nano 9.11(2015):11455-11461.

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