One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer

	One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer
	Zheng, M.; S. Liu; X. G. Guan and Z. G. Xie
	2015
发表期刊	Acs Applied Materials & Interfaces
卷号	7 期号:40 页码:22181-22187
摘要	A straightforward nanoprecipitating method was developed to prepare water dispersible curcumin (CCM)-loaded nanoscale zeolitic imidazolate framework-8 (CCM@NZIF-8) nanopartides (NPs). The as-synthesized CCM@NZIF-8 NPs possess high drug encapsulation efficiency (88.2%), good chemical stability and fast drug release in tumor acidic microenvironments. Confocal laser scanning microscopy and cytotoxicity experiments reveal that NZIF-8 based nanocarriers promote the cellular uptake of CCM and result in higher cytotoxicity of CCM@NZIF-8 than that of free CCM toward HeLa cells. The in vivo anticancer experiments indicate that CCM@NZIF-8 NPs exhibit much higher antitumor efficacy than free CCM. This work highlights the potential of using nanoscale metal organic framworks (NMOFs) as a simple and stable platform for developing a highly efficient drug delivery system in cancer treatment.
收录类别	SCI ; EI
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/55533
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	Zheng, M.,S. Liu,X. G. Guan and Z. G. Xie. One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer[J]. Acs Applied Materials & Interfaces,2015,7(40):22181-22187.
APA	Zheng, M.,S. Liu,&X. G. Guan and Z. G. Xie.(2015).One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer.Acs Applied Materials & Interfaces,7(40),22181-22187.
MLA	Zheng, M.,et al."One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer".Acs Applied Materials & Interfaces 7.40(2015):22181-22187.

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