In vivo 808 nm image-guided photodynamic therapy based on an upconversion theranostic nanoplatform

	In vivo 808 nm image-guided photodynamic therapy based on an upconversion theranostic nanoplatform
	Liu, X. M.; I. Que; X. G. Kong; Y. L. Zhang; L. P. Tu; Y. L. Chang; T. T. Wang; A. Chan; C. Lowik and H. Zhang
	2015
发表期刊	Nanoscale
卷号	7 期号:36 页码:14914-14923
摘要	A new strategy for efficient in vivo image-guided photodynamic therapy (PDT) has been demonstrated utilizing a ligand-exchange constructed upconversion-C-60 nanophotosensitizer. This theranostic platform is superior to the currently reported nanophotosensitizers in (i) directly bonding photosensitizer C-60 to the surface of upconversion nanoparticles (UCNPs) by a smart ligand-exchange strategy, which greatly shortened the energy transfer distance and enhanced the O-1(2) production, resulting in the improvement of the therapeutic effect; (ii) realizing in vivo NIR 808 nm image-guided PDT with both excitation (980 nm) and emission (808 nm) light falling in the biological window of tissues, which minimized auto-fluorescence, reduced light scatting and improved the imaging contrast and depth, and thus guaranteed noninvasive diagnostic accuracy. In vivo and ex vivo tests demonstrated its favorable bio-distribution, tumor-selectivity and high therapeutic efficacy. Owing to the effective ligand exchange strategy and the excellent intrinsic photophysical properties of C-60, O-1(2) production yield was improved, suggesting that a low 980 nm irradiation dosage (351 J cm(-2)) and a short treatment time (15 min) were sufficient to perform NIR (980 nm) to NIR (808 nm) image-guided PDT. Our work enriches the understanding of UCNP-based PDT nanophotosensitizers and highlights their potential use in future NIR image-guided noninvasive deep cancer therapy.
收录类别	SCI ; EI
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/55327
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	Liu, X. M.,I. Que,X. G. Kong,et al. In vivo 808 nm image-guided photodynamic therapy based on an upconversion theranostic nanoplatform[J]. Nanoscale,2015,7(36):14914-14923.
APA	Liu, X. M..,I. Que.,X. G. Kong.,Y. L. Zhang.,L. P. Tu.,...&C. Lowik and H. Zhang.(2015).In vivo 808 nm image-guided photodynamic therapy based on an upconversion theranostic nanoplatform.Nanoscale,7(36),14914-14923.
MLA	Liu, X. M.,et al."In vivo 808 nm image-guided photodynamic therapy based on an upconversion theranostic nanoplatform".Nanoscale 7.36(2015):14914-14923.

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