Pneumatic-pumping metering in CD-like microfluidic chip for whole blood analysis

	Pneumatic-pumping metering in CD-like microfluidic chip for whole blood analysis
	Fan J.-H.; Deng Y.-B.; Xuan M.; Zhou S.; Wu J.-F.; Liu Y.-S.; Wu Y.-H.
	2014
发表期刊	Guangxue Jingmi Gongcheng/Optics and Precision Engineering
ISSN	ISBN/1004924X
卷号	22 期号:10 页码:2733-2739
摘要	To overcome the dependence of the plasma extraction on siphon hydrophilicity in a centrifugal microfluidic chip and to ensure long-term stability and reliability of the microfluidic chip, a compressed air reservoir connected to the blood separated reservoir was proposed to separate the blood in blood separated reservoir at high rotating speeds. Through lowering the spinning speed, the plasma in the separated reservoir was pumped toward the CD-like chip center to release the stored air pressure produced by the rotation at high spinning speeds. Based on the thermodynamics of the isothermal gas, the pneumatic pumping method was modeled, and the model was confirmed by analyzing pumping positions and air compression versus spinning speeds. By using the layered Polymethyl Methacrylate(PMMA)as materials, the centrifugal microfluidic chips for plasma extraction were fabricated with a CO2 laser process technique and the volume of compressed air and the blood position at siphon were tested at different rotational speeds. Experimental results demonstrate that the achieved volume of compression is 8.7L and the siphon valve effectively inhibits whole blood to overflow the crest of siphon at 4 000 r/min speed. With lowering the spin speed to 1 000 r/min, the release of compressed air overcomes the centrifugal force and drives the plasma to flow past the crest of siphon. Then the plasma extraction is realized in quantitation.
收录类别	EI
语种	中文
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/44274
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	Fan J.-H.,Deng Y.-B.,Xuan M.,et al. Pneumatic-pumping metering in CD-like microfluidic chip for whole blood analysis[J]. Guangxue Jingmi Gongcheng/Optics and Precision Engineering,2014,22(10):2733-2739.
APA	Fan J.-H..,Deng Y.-B..,Xuan M..,Zhou S..,Wu J.-F..,...&Wu Y.-H..(2014).Pneumatic-pumping metering in CD-like microfluidic chip for whole blood analysis.Guangxue Jingmi Gongcheng/Optics and Precision Engineering,22(10),2733-2739.
MLA	Fan J.-H.,et al."Pneumatic-pumping metering in CD-like microfluidic chip for whole blood analysis".Guangxue Jingmi Gongcheng/Optics and Precision Engineering 22.10(2014):2733-2739.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
CD-like全血分析芯片内压缩空气的定（1574KB）			开放获取	CC BY-ND	浏览下载