Inhibitation of Cellular Toxicity of Gold Nanoparticles by Surface Encapsulation of Silica Shell for Hepatocarcinoma Cell Application

	Inhibitation of Cellular Toxicity of Gold Nanoparticles by Surface Encapsulation of Silica Shell for Hepatocarcinoma Cell Application
	Zeng Q. H.; Zhang Y. L.; Ji W. Y.; Ye W. G.; Jiang Y. L.; Song J.
	2014
发表期刊	Acs Applied Materials & Interfaces
ISSN	ISBN/1944-8244
卷号	6 期号:21 页码:19327-19335
摘要	Nanotechnology, as a double-edged sword, endows gold nanoparticles (GNPs) more "power" in bioimaging and theragnostics, whereas an outstanding issue associated with the biocompatibility of GNPs should also be addressed. Especially for the silica-coated gold nanospheres (GNSs) and gold nanorods (GNRs), there is increasing attention to explore the application, because the surface silica encapsulation has been proved to be an alternative strategy for other organic surface coatings. However, among those reports there are very limited publications to focus on the toxicity of silica-coated GNSs and GNRs. Besides, the existing detoxification methods via surface chemistry on GNPs greatly improve the biocompatibility but still undergo challenges for high dose (>100 pM) demand and long-term stability. Here, we demonstrated a straightforward, low-cost, universal strategy for the surface chemistry on GNPs via silica encapsulating. Different size, shape, dose, and surface capping of GNPs for the nanotoxicity test have been carefully discussed. After silica encapsulating, the detoxification for all GNPs presents significantly from HepG2 cell proliferation results, especially for the GNRs. This new straightforward strategy will definitely rationalize the biocompatibility issue of GNPs and also provide potential for other surface chemistry methodology in biomedical fields.
收录类别	SCI ; EI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/44094
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	Zeng Q. H.,Zhang Y. L.,Ji W. Y.,et al. Inhibitation of Cellular Toxicity of Gold Nanoparticles by Surface Encapsulation of Silica Shell for Hepatocarcinoma Cell Application[J]. Acs Applied Materials & Interfaces,2014,6(21):19327-19335.
APA	Zeng Q. H.,Zhang Y. L.,Ji W. Y.,Ye W. G.,Jiang Y. L.,&Song J..(2014).Inhibitation of Cellular Toxicity of Gold Nanoparticles by Surface Encapsulation of Silica Shell for Hepatocarcinoma Cell Application.Acs Applied Materials & Interfaces,6(21),19327-19335.
MLA	Zeng Q. H.,et al."Inhibitation of Cellular Toxicity of Gold Nanoparticles by Surface Encapsulation of Silica Shell for Hepatocarcinoma Cell Application".Acs Applied Materials & Interfaces 6.21(2014):19327-19335.

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