Gold nanoparticle amplified optical microfiber evanescent wave absorption biosensor for cancer biomarker detection in serum

	Gold nanoparticle amplified optical microfiber evanescent wave absorption biosensor for cancer biomarker detection in serum
	Li K. W.; Liu G. G.; Wu Y. H.; Hao P.; Zhou W. C.; Zhang Z. Q.
	2014
发表期刊	Talanta
ISSN	ISBN/0039-9140
期号	120 页码:419-424
摘要	Sensitive and selective detection for cancer biomarkers is critical in cancer clinical diagnostics. In this work, we report a new optical microfiber (OMF) biosensor using gold nanoparticles (GNPs) as amplification labels for the detection of alpha-fetoprotein (AFP) in serum samples. By combining the unique optical property of OMFs and the strong optical absorption of GNPs, very high sensitivity and selectivity can be achieved. Critical parameters namely fiber diameter and GNP size were optimized for better performance. The limit of detection (LOD) of this sensor for AFP is 0.2 ng/mL in PBS and 2 ng/mL in bovine serum, which is comparable to conventional assays. The advantages of this biosensor are simple detection scheme, fast response time, and ease of miniaturization, which might make this biosensor a promising platform for clinical cancer diagnosis and prognosis. (C) 2013 Elsevier B.V. All rights reserved.
收录类别	SCI ; EI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/44013
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	Li K. W.,Liu G. G.,Wu Y. H.,et al. Gold nanoparticle amplified optical microfiber evanescent wave absorption biosensor for cancer biomarker detection in serum[J]. Talanta,2014(120):419-424.
APA	Li K. W.,Liu G. G.,Wu Y. H.,Hao P.,Zhou W. C.,&Zhang Z. Q..(2014).Gold nanoparticle amplified optical microfiber evanescent wave absorption biosensor for cancer biomarker detection in serum.Talanta(120),419-424.
MLA	Li K. W.,et al."Gold nanoparticle amplified optical microfiber evanescent wave absorption biosensor for cancer biomarker detection in serum".Talanta .120(2014):419-424.

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