INI1/hSNF5/BAF47 represses c-fos transcription via a histone deacetylase-dependent manner

	INI1/hSNF5/BAF47 represses c-fos transcription via a histone deacetylase-dependent manner
其他题名	论文其他题名
	Pan X. F.; Zhai L.; Sun R.; Li X. Y.; Zeng X. L.
	2005
发表期刊	Biochemical and Biophysical Research Communications
ISSN	0006-291X
卷号	337 期号:4 页码:1052-1058
摘要	INI1/hSNF5/BAF47 is a core component of the hSWI/SNF ATP-dependent chromatin-remodeling complex. It has been suggested that INI1/hSNF5/BAF47 contributes to the regulation of many genes. In this report, we showed that the overexpression of INI1/hSNF5/BAF47 repressed c-fos promoter activity and endogenous c-fos transcription in 293T cells, and the siRNA targeting INI1/hSNF5/BAF47 (siINI1) reversed the inhibitory effect. Histone deacetylation by histone deacetylases (HDACs) was necessary for the repression of c-fos transcription by INI1/hSNF5/BAF47. HDAC and INJI/hSNF5/BAF47 functioned together to suppress c-fos transcription. ChIP experiments demonstrated that INI1/hSNF5/BAF47 could be recruited to the region of c-fos promoter to reduce histone acetylation. Altogether, these data show that INI1/hSNF5/BAF47 represses c-jbs transcription via a histone deacetylase (HDAC)-dependent manner. (c) 2005 Elsevier Inc. All rights reserved.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/25005
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	Pan X. F.,Zhai L.,Sun R.,et al. INI1/hSNF5/BAF47 represses c-fos transcription via a histone deacetylase-dependent manner[J]. Biochemical and Biophysical Research Communications,2005,337(4):1052-1058.
APA	Pan X. F.,Zhai L.,Sun R.,Li X. Y.,&Zeng X. L..(2005).INI1/hSNF5/BAF47 represses c-fos transcription via a histone deacetylase-dependent manner.Biochemical and Biophysical Research Communications,337(4),1052-1058.
MLA	Pan X. F.,et al."INI1/hSNF5/BAF47 represses c-fos transcription via a histone deacetylase-dependent manner".Biochemical and Biophysical Research Communications 337.4(2005):1052-1058.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Pan-2005-INI1_hSNF5_（262KB）			开放获取	--	浏览下载