Changchun Institute of Optics,Fine Mechanics and Physics,CAS
INI1/hSNF5/BAF47 represses c-fos transcription via a histone deacetylase-dependent manner | |
其他题名 | 论文其他题名 |
Pan X. F.; Zhai L.; Sun R.; Li X. Y.; Zeng X. L. | |
2005 | |
发表期刊 | Biochemical and Biophysical Research Communications
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ISSN | 0006-291X |
卷号 | 337期号:4页码:1052-1058 |
摘要 | INI1/hSNF5/BAF47 is a core component of the hSWI/SNF ATP-dependent chromatin-remodeling complex. It has been suggested that INI1/hSNF5/BAF47 contributes to the regulation of many genes. In this report, we showed that the overexpression of INI1/hSNF5/BAF47 repressed c-fos promoter activity and endogenous c-fos transcription in 293T cells, and the siRNA targeting INI1/hSNF5/BAF47 (siINI1) reversed the inhibitory effect. Histone deacetylation by histone deacetylases (HDACs) was necessary for the repression of c-fos transcription by INI1/hSNF5/BAF47. HDAC and INJI/hSNF5/BAF47 functioned together to suppress c-fos transcription. ChIP experiments demonstrated that INI1/hSNF5/BAF47 could be recruited to the region of c-fos promoter to reduce histone acetylation. Altogether, these data show that INI1/hSNF5/BAF47 represses c-jbs transcription via a histone deacetylase (HDAC)-dependent manner. (c) 2005 Elsevier Inc. All rights reserved. |
收录类别 | SCI |
语种 | 英语 |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ciomp.ac.cn/handle/181722/25005 |
专题 | 中科院长春光机所知识产出 |
推荐引用方式 GB/T 7714 | Pan X. F.,Zhai L.,Sun R.,et al. INI1/hSNF5/BAF47 represses c-fos transcription via a histone deacetylase-dependent manner[J]. Biochemical and Biophysical Research Communications,2005,337(4):1052-1058. |
APA | Pan X. F.,Zhai L.,Sun R.,Li X. Y.,&Zeng X. L..(2005).INI1/hSNF5/BAF47 represses c-fos transcription via a histone deacetylase-dependent manner.Biochemical and Biophysical Research Communications,337(4),1052-1058. |
MLA | Pan X. F.,et al."INI1/hSNF5/BAF47 represses c-fos transcription via a histone deacetylase-dependent manner".Biochemical and Biophysical Research Communications 337.4(2005):1052-1058. |
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