Homoisoflavanones from Polygonatum odoratum Rhizomes Inhibit Advanced Glycation End Product Formation

	Homoisoflavanones from Polygonatum odoratum Rhizomes Inhibit Advanced Glycation End Product Formation
其他题名	论文其他题名
	Dong W.; Shi H. B.; Ma H.; Miao Y. B.; Liu T. J.; Wang W.
	2010
发表期刊	Archives of Pharmacal Research
ISSN	0253-6269
卷号	33 期号:5 页码:669-674
摘要	Protein glycation inhibitors from Polygonatum odoratum rhizomes were investigated using a bioassay-guided procedure to characterize active compounds for preventing and treating diabetic complications. The EtOH extract and soluble fractions were evaluated using an in vivo model of renal advanced glycation end-product (AGE) accumulation in streptozotocin-induced diabetic rats and an in vitro bovine serum albumin-glucose assay. Three homoisoflavanones 3-(4'-hydroxybenzyl)-5,7-dihydroxy-6-methyl-8-methoxychroman-4-one (1), 3-(4'-hydroxybenzyl)-5,7-dihydroxy-6,8-dimethylchroman-4-one (2), and 3-(4'-methoxybenzyl)-5,7-dihydroxy-6-methyl-8-methoxychroman-4-one (3), isolated from the active CHCl(3)-soluble fraction of the EtOH extract, were subjected to in vitro bioassays to evaluate their inhibitory activities against AGE formation. All the isolates inhibited AGE formation more effectively than the positive control, aminoguanidine. These results indicate that pending further study these compounds could be used as novel natural product drug for mitigating diabetic complications.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/24773
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	Dong W.,Shi H. B.,Ma H.,et al. Homoisoflavanones from Polygonatum odoratum Rhizomes Inhibit Advanced Glycation End Product Formation[J]. Archives of Pharmacal Research,2010,33(5):669-674.
APA	Dong W.,Shi H. B.,Ma H.,Miao Y. B.,Liu T. J.,&Wang W..(2010).Homoisoflavanones from Polygonatum odoratum Rhizomes Inhibit Advanced Glycation End Product Formation.Archives of Pharmacal Research,33(5),669-674.
MLA	Dong W.,et al."Homoisoflavanones from Polygonatum odoratum Rhizomes Inhibit Advanced Glycation End Product Formation".Archives of Pharmacal Research 33.5(2010):669-674.

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