中国科学院长春光学精密机械与物理研究所

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	Multi-dimensional plasmonic coupling system for efficient enrichment and ultrasensitive label-free SERS detection of bilirubin based on graphene oxide-Au nanostars and Au@Ag nanoparticles
	W. Zhao, S. Yang, D. Zhang, T. Zhou, J. Huang, M. Gao, X. Zhang, Y. Liu and J. Yang
	2023
发表期刊	Journal of Colloid and Interface Science
ISSN	00219797
卷号	646页码:872-882
摘要	Rapid and sensitive detection of free bilirubin (BR) is essential for early diagnosis of jaundice and other hepatobiliary diseases. Inspired by sandwich immunoassay strategy, a multi-dimensional plasmonic coupling SERS platform composed of graphene oxide-Au nanostars nanocomposites (GANS NCs) and Au@Ag nanoparticles (NPs) was designed for label-free detection of BR. Specifically, GANS NCs were first prepared, and their excellent SERS activity was ascribed to synergistic enhancement effect of electromagnetic enhancement and chemical enhancement. Furthermore, SERS spectroscopy was used to monitor the adsorption process of BR. Subsequently, secondary reinforcing Au@Ag NPs were directly added, ultimately resulting in a multi-dimensional plasmonic coupling effect. The SERS enhancing mechanism of coupled system was discussed through electromagnetic field simulations. Interestingly, the high-density hotspots generated by strong plasmonic coupling in GANS-Au@Ag substrate could lead to more extraordinary SERS enhancing behavior compared to GANS NCs. Sensing efficiency of the SERS platform was examined by BR with a detection limit down to 10−11 M. Besides, GANS-Au@Ag NCs performed high uniformity and reproducibility. This work not only opens up a new avenue for construction of multi-dimensional plasmonic coupling system, but also offers a new biosensing technology for label-free diagnosis of BR-related diseases, thereby expecting to be applied in clinical diagnosis. © 2023 Elsevier Inc.
DOI	10.1016/j.jcis.2023.05.117
URL	查看原文
收录类别	sci ; ei
引用统计
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/68239
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	W. Zhao, S. Yang, D. Zhang, T. Zhou, J. Huang, M. Gao, X. Zhang, Y. Liu and J. Yang. Multi-dimensional plasmonic coupling system for efficient enrichment and ultrasensitive label-free SERS detection of bilirubin based on graphene oxide-Au nanostars and Au@Ag nanoparticles[J]. Journal of Colloid and Interface Science,2023,646:872-882.
APA	W. Zhao, S. Yang, D. Zhang, T. Zhou, J. Huang, M. Gao, X. Zhang, Y. Liu and J. Yang.(2023).Multi-dimensional plasmonic coupling system for efficient enrichment and ultrasensitive label-free SERS detection of bilirubin based on graphene oxide-Au nanostars and Au@Ag nanoparticles.Journal of Colloid and Interface Science,646,872-882.
MLA	W. Zhao, S. Yang, D. Zhang, T. Zhou, J. Huang, M. Gao, X. Zhang, Y. Liu and J. Yang."Multi-dimensional plasmonic coupling system for efficient enrichment and ultrasensitive label-free SERS detection of bilirubin based on graphene oxide-Au nanostars and Au@Ag nanoparticles".Journal of Colloid and Interface Science 646(2023):872-882.

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