CIOMP OpenIR
Ginsenoside Rg1 Delays Chronological Aging in a Yeast Model via CDC19-and SDH2-Mediated Cellular Metabolism
S. M. Wang, J. H. Qiao, C. Y. Jiang, D. A. Pan, S. T. Yu, J. J. Chen, S. C. Liu, P. G. Zhang, D. Q. Zhao and M. C. Liu
2023
Source PublicationAntioxidants
Volume12Issue:2Pages:20
AbstractGinsenosides, active substances in Panax ginseng C. A. Meyer (ginseng), extend lifespan in multiple species, ameliorate age-associated damage, and limit functional decline in multiple tissues. However, their active components and their molecular mechanisms are largely unknown. Here, ginsenoside Rg1 (Rg1) promoted longevity in Saccharomyces cerevisiae. Treatment with Rg1 decreased aging-mediated surface wrinkling, enhanced stress resistance, decreased reactive oxygen species' production and apoptosis, improved antioxidant enzyme activity, and decreased the aging rate. Proteomic analysis indicated that Rg1 delays S. cerevisiae senescence by regulating metabolic homeostasis. Protein-protein interaction networks based on differential protein expression indicated that CDC19, a homologue of pyruvate kinase, and SDH2, the succinate dehydrogenase iron-sulfur protein subunit, might be the effector proteins involved in the regulation by Rg1. Further experiments confirmed that Rg1 improved specific parameters of mitochondrial bioenergetics and core enzymes in the glycolytic pathway. Mutant strains were constructed that demonstrated the relationships between metabolic homeostasis and the predicted target proteins of Rg1. Rg1 could be used in new treatments for slowing the aging process. Our results also provide a useful dataset for further investigations of the mechanisms of ginseng in aging.
DOI10.3390/antiox12020296
URL查看原文
Indexed Bysci
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ciomp.ac.cn/handle/181722/67960
Collection中国科学院长春光学精密机械与物理研究所
Recommended Citation
GB/T 7714
S. M. Wang, J. H. Qiao, C. Y. Jiang, D. A. Pan, S. T. Yu, J. J. Chen, S. C. Liu, P. G. Zhang, D. Q. Zhao and M. C. Liu. Ginsenoside Rg1 Delays Chronological Aging in a Yeast Model via CDC19-and SDH2-Mediated Cellular Metabolism[J]. Antioxidants,2023,12(2):20.
APA S. M. Wang, J. H. Qiao, C. Y. Jiang, D. A. Pan, S. T. Yu, J. J. Chen, S. C. Liu, P. G. Zhang, D. Q. Zhao and M. C. Liu.(2023).Ginsenoside Rg1 Delays Chronological Aging in a Yeast Model via CDC19-and SDH2-Mediated Cellular Metabolism.Antioxidants,12(2),20.
MLA S. M. Wang, J. H. Qiao, C. Y. Jiang, D. A. Pan, S. T. Yu, J. J. Chen, S. C. Liu, P. G. Zhang, D. Q. Zhao and M. C. Liu."Ginsenoside Rg1 Delays Chronological Aging in a Yeast Model via CDC19-and SDH2-Mediated Cellular Metabolism".Antioxidants 12.2(2023):20.
Files in This Item: Download All
File Name/Size DocType Version Access License
Ginsenoside Rg1 Dela(8841KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[S. M. Wang, J. H. Qiao, C. Y. Jiang, D. A. Pan, S. T. Yu, J. J. Chen, S. C. Liu, P. G. Zhang, D. Q. Zhao and M. C. Liu]'s Articles
Baidu academic
Similar articles in Baidu academic
[S. M. Wang, J. H. Qiao, C. Y. Jiang, D. A. Pan, S. T. Yu, J. J. Chen, S. C. Liu, P. G. Zhang, D. Q. Zhao and M. C. Liu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[S. M. Wang, J. H. Qiao, C. Y. Jiang, D. A. Pan, S. T. Yu, J. J. Chen, S. C. Liu, P. G. Zhang, D. Q. Zhao and M. C. Liu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Ginsenoside Rg1 Delays Chronological Aging in.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.