Changchun Institute of Optics,Fine Mechanics and Physics,CAS
| Preparation and Properties of Sodium Alginate/Gelatin Hydrogel-Microspheres | |
| W. J. Tang, J. X. Zhang, L. Liu, L. Y. Zhao, L. Wang, C. Shi, Y. Liu and M. L. Wen | |
| 2024 | |
| Source Publication | Journal of Macromolecular Science Part B-Physics
 |
| ISSN | 0022-2348 |
| Volume | 63Issue:3Pages:146-160 |
| Abstract | Calcium alginate gel microspheres exhibiting pH response release characteristics were prepared, and utilizing Bovine serum albumin (BSA) to evaluate drug release performance. Hydrogels composed of gelatin (GL) and sodium alginate oxide (NALO), with varying ratios (7:3; 4:1; 3:2) were prepared by controlling their composition. Scanning electron microscopy (SEM) and a microplate reader (ELIASA) were used to characterize the microspheres' microstructure and in vitro BSA release behavior, respectively. The results demonstrated that, under acidic conditions, the BSA release was slower than in neutral conditions. The hydrogels' physical and chemical properties were analyzed using optical microscopy, Fourier transform infrared spectroscopy (FTIR), swelling experiments and mechanical testing of the hydrogels and microsphere loaded hydrogels. The results showed that a GL to NALO ratio of 7:3 increased the swelling degree, while a 4:1 ratio optimized the mechanical characteristics. The study concluded that the microsphere-loaded hydrogels exhibited significant potential for human drug delivery applications. |
| DOI | 10.1080/00222348.2023.2254578 |
| URL | 查看原文 |
| Indexed By | sci |
| Language | 英语 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ciomp.ac.cn/handle/181722/67890 |
| Collection | 中国科学院长春光学精密机械与物理研究所 |
| Recommended Citation GB/T 7714 | W. J. Tang, J. X. Zhang, L. Liu, L. Y. Zhao, L. Wang, C. Shi, Y. Liu and M. L. Wen. Preparation and Properties of Sodium Alginate/Gelatin Hydrogel-Microspheres[J]. Journal of Macromolecular Science Part B-Physics,2024,63(3):146-160. |
| APA | W. J. Tang, J. X. Zhang, L. Liu, L. Y. Zhao, L. Wang, C. Shi, Y. Liu and M. L. Wen.(2024).Preparation and Properties of Sodium Alginate/Gelatin Hydrogel-Microspheres.Journal of Macromolecular Science Part B-Physics,63(3),146-160. |
| MLA | W. J. Tang, J. X. Zhang, L. Liu, L. Y. Zhao, L. Wang, C. Shi, Y. Liu and M. L. Wen."Preparation and Properties of Sodium Alginate/Gelatin Hydrogel-Microspheres".Journal of Macromolecular Science Part B-Physics 63.3(2024):146-160. |
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| Preparation and Prop（1587KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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