Preparation and Properties of Sodium Alginate/Gelatin Hydrogel-Microspheres

doi:10.1080/00222348.2023.2254578

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	Preparation and Properties of Sodium Alginate/Gelatin Hydrogel-Microspheres
	W. J. Tang, J. X. Zhang, L. Liu, L. Y. Zhao, L. Wang, C. Shi, Y. Liu and M. L. Wen
	2024
发表期刊	Journal of Macromolecular Science Part B-Physics
ISSN	0022-2348
卷号	63 期号:3 页码:146-160
摘要	Calcium alginate gel microspheres exhibiting pH response release characteristics were prepared, and utilizing Bovine serum albumin (BSA) to evaluate drug release performance. Hydrogels composed of gelatin (GL) and sodium alginate oxide (NALO), with varying ratios (7:3; 4:1; 3:2) were prepared by controlling their composition. Scanning electron microscopy (SEM) and a microplate reader (ELIASA) were used to characterize the microspheres' microstructure and in vitro BSA release behavior, respectively. The results demonstrated that, under acidic conditions, the BSA release was slower than in neutral conditions. The hydrogels' physical and chemical properties were analyzed using optical microscopy, Fourier transform infrared spectroscopy (FTIR), swelling experiments and mechanical testing of the hydrogels and microsphere loaded hydrogels. The results showed that a GL to NALO ratio of 7:3 increased the swelling degree, while a 4:1 ratio optimized the mechanical characteristics. The study concluded that the microsphere-loaded hydrogels exhibited significant potential for human drug delivery applications.
DOI	10.1080/00222348.2023.2254578
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收录类别	sci
语种	英语
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文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/67890
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	W. J. Tang, J. X. Zhang, L. Liu, L. Y. Zhao, L. Wang, C. Shi, Y. Liu and M. L. Wen. Preparation and Properties of Sodium Alginate/Gelatin Hydrogel-Microspheres[J]. Journal of Macromolecular Science Part B-Physics,2024,63(3):146-160.
APA	W. J. Tang, J. X. Zhang, L. Liu, L. Y. Zhao, L. Wang, C. Shi, Y. Liu and M. L. Wen.(2024).Preparation and Properties of Sodium Alginate/Gelatin Hydrogel-Microspheres.Journal of Macromolecular Science Part B-Physics,63(3),146-160.
MLA	W. J. Tang, J. X. Zhang, L. Liu, L. Y. Zhao, L. Wang, C. Shi, Y. Liu and M. L. Wen."Preparation and Properties of Sodium Alginate/Gelatin Hydrogel-Microspheres".Journal of Macromolecular Science Part B-Physics 63.3(2024):146-160.

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