Emerging single-cell microfluidic technology for microbiology

doi:10.1016/j.trac.2023.117444

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	Emerging single-cell microfluidic technology for microbiology
	Y. Q. Song, J. N. Yin, W. E. Huang, B. Li and H. B. Yin
	2024
发表期刊	Trac-Trends in Analytical Chemistry
ISSN	0165-9936
卷号	170 页码:17
摘要	Cell-to-cell differences exist ubiquitously in microbial communities. This individual heterogeneity, often manifested in cell phenotypic function (e.g., antibiotic resistance), can be critical in determining the fate of a microbial community. However, studying such heterogeneity in microbial communities remains a significant challenge due to their enormous diversity and complex cell-cell interactions. Here we review recent advances in microfluidic technologies for detecting, manipulating, and sorting microbial populations at the single-cell level, which significantly advanced our understanding of microbial behaviour and their roles in the microbial ecosystem. We will highlight microfluidic systems with label-free detection methods, including optical imaging and Raman spectroscopy, due to their advantages in investigating real-world microbial communities. We will showcase these technologies in emerging applications, including rapid diagnosis of pathogens and antibiotic resistance, chemotaxis, and Raman-activated cell sorting to search for natural microbial cells of desirable phenotypic function.
DOI	10.1016/j.trac.2023.117444
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收录类别	sci
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/67856
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	Y. Q. Song, J. N. Yin, W. E. Huang, B. Li and H. B. Yin. Emerging single-cell microfluidic technology for microbiology[J]. Trac-Trends in Analytical Chemistry,2024,170:17.
APA	Y. Q. Song, J. N. Yin, W. E. Huang, B. Li and H. B. Yin.(2024).Emerging single-cell microfluidic technology for microbiology.Trac-Trends in Analytical Chemistry,170,17.
MLA	Y. Q. Song, J. N. Yin, W. E. Huang, B. Li and H. B. Yin."Emerging single-cell microfluidic technology for microbiology".Trac-Trends in Analytical Chemistry 170(2024):17.

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