Applications of single-site iron nanozymes in biomedicine

doi:10.1016/j.ccr.2023.215209

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	Applications of single-site iron nanozymes in biomedicine
	J. Y. Han and J. Q. Guan
	2023
发表期刊	Coordination Chemistry Reviews
ISSN	0010-8545
卷号	490 页码:32
摘要	With the vigorous development of nanozymes in recent years, single-site nanozymes (SSNs) with maximum atomic utilization of 100% have become a popular research frontier in various fields due to their tremendous advantages in both catalytic activity and selectivity. As for biomedicine, Fe-based SSNs not only have a high abundance of earth resources, but also share the normal Fe-Nx coordination structure, which is extremely similar to that of natural bioenzymes. Moreover, Fe ions play a crucial role in the Fenton response, exhibiting superior therapeutic effects. These unique advantages allow Fe-based SSNs to greatly shine in the biomedicine. In this review, we first describe the characterization and synthesis methods of atomic level sites. Then the biochemical action mechanism and in vivo pharmacokinetics of Fe-based SSNs is outlined. Following, we emphatically summarize the latest biomedical research and applications according to different application directions (including disease treatment, antibacterial wound disinfection, biosensing and oxidative stress cytoprotecting). Finally, a concise but directly summary and perspective is provided to outline the challenges for the future development of Fe-based SSNs for biomedical applications.
DOI	10.1016/j.ccr.2023.215209
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收录类别	sci
语种	英语
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/67511
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	J. Y. Han and J. Q. Guan. Applications of single-site iron nanozymes in biomedicine[J]. Coordination Chemistry Reviews,2023,490:32.
APA	J. Y. Han and J. Q. Guan.(2023).Applications of single-site iron nanozymes in biomedicine.Coordination Chemistry Reviews,490,32.
MLA	J. Y. Han and J. Q. Guan."Applications of single-site iron nanozymes in biomedicine".Coordination Chemistry Reviews 490(2023):32.

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