High-sensitivity hemoglobin detection based on polarization-differential spectrophotometry

doi:10.1016/j.bios.2023.115667

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	High-sensitivity hemoglobin detection based on polarization-differential spectrophotometry
	C. Deng, Q. Zhao, Y. Gan, C. Yang, H. Zhu, S. Mo, J. Zheng, J. Li, K. Jiang, Z. Feng, X. Wei, Q. Zhang, Z. Yang and S. Xu
	2023
Source Publication	Biosensors and Bioelectronics
ISSN	09565663
Volume	241
Abstract	Hemoglobin content is recognized as a momentous and fundamental physiological indicator, especially the precise detection of trace hemoglobin is of great significance for early diagnosis and prevention of tumors, cancer, organic injury, etc. Therefore, high-sensitivity hemoglobin detection is imperative. However, effective detection methods and reliable detection systems are still lacking and remain enormous challenges. Herein, we present a synthetical strategy to break through the existing bottleneck based on polarization-differential spectrophotometry and high-performance single-frequency green fiber laser. Importantly, this framework not only has precisely extracted the two-dimensional information of intensity and polarization during the interaction between laser and hemoglobin, but also has taken advantage of the high monochromaticity and fine directivity in the optimized laser source to reduce the undesirable scattered disturbance. Thus, the hemoglobin detection sensitivity of 7.2 × 10−5 g/L has advanced a hundredfold compared with conventional spectrophotometry, and the responsive dynamic range is close to six orders of magnitude. Results indicate that our technology can realize high-sensitivity detection of trace hemoglobin content, holding promising applications for precision medicine and early diagnosis as an optical direct and fast detection method. © 2023 Elsevier B.V.
DOI	10.1016/j.bios.2023.115667
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Indexed By	sci ; ei
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Document Type	期刊论文
Identifier	http://ir.ciomp.ac.cn/handle/181722/67427
Collection	中国科学院长春光学精密机械与物理研究所
Recommended Citation GB/T 7714	C. Deng, Q. Zhao, Y. Gan, C. Yang, H. Zhu, S. Mo, J. Zheng, J. Li, K. Jiang, Z. Feng, X. Wei, Q. Zhang, Z. Yang and S. Xu. High-sensitivity hemoglobin detection based on polarization-differential spectrophotometry[J]. Biosensors and Bioelectronics,2023,241.
APA	C. Deng, Q. Zhao, Y. Gan, C. Yang, H. Zhu, S. Mo, J. Zheng, J. Li, K. Jiang, Z. Feng, X. Wei, Q. Zhang, Z. Yang and S. Xu.(2023).High-sensitivity hemoglobin detection based on polarization-differential spectrophotometry.Biosensors and Bioelectronics,241.
MLA	C. Deng, Q. Zhao, Y. Gan, C. Yang, H. Zhu, S. Mo, J. Zheng, J. Li, K. Jiang, Z. Feng, X. Wei, Q. Zhang, Z. Yang and S. Xu."High-sensitivity hemoglobin detection based on polarization-differential spectrophotometry".Biosensors and Bioelectronics 241(2023).

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中国科学院长春光学精密机械与物理研究所