Amplification of oxidative damage using near-infrared II-mediated photothermal/thermocatalytic effects for periodontitis treatment

doi:10.1016/j.actbio.2023.09.014

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	Amplification of oxidative damage using near-infrared II-mediated photothermal/thermocatalytic effects for periodontitis treatment
	X. Dai, Y. Liu, F. Meng, Q. Li, F. Wu, J. Yuan, H. Chen, H. Lv, Y. Zhou and Y. Chang
	2023
Source Publication	Acta Biomaterialia
ISSN	17427061
Volume	171 Pages:519-531
Abstract	Periodontitis is a biofilm-related disease characterized by damage to the periodontal tissue and the development of systemic diseases. However, treatment of periodontitis remains unsatisfactory, especially with deep-tissue infections. This study describes rationally designed multifunctional photothermocatalytic agents for near-infrared-II light-mediated synergistic antibiofilm treatment, through modification of Lu-Bi2Te3 with Fe3O4 and poly(ethylene glycol)-b-poly(l-arginine) (PEG-b-PArg). Notably, 1064-nm laser irradiation led to photothermal/thermocatalytic effects, resulting in the synergistic generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and consequent damage to the biofilm. This treatment was based on the thermoelectric and photothermal conversion properties of Lu-Bi2Te3, the peroxidase-like catalytic capacity of Fe3O4, and the guanidinium polymer, PEG-b-PArg. Oxidative damage to biofilm was further enhanced by H2O2, resulting in the effective elimination of biofilm both in vitro and in vivo. These findings suggest that this synergistic therapeutic strategy is effective for the clinical treatment of periodontitis. Statement of significance: The current treatment for periodontitis involves time-consuming and labor-intensive clinical scaling of the teeth. The present study is the first to assess the efficacy of a photothermal catalyst for periodontitis treatment. This used near-infrared-II light at 1064 nm to induce oxidative damage in the biofilm, resulting in its degradation. The synergistic photothermal/thermoelectric effect produced deep tissue penetration and was well tolerated, and can kill the biofilm formed by periodontitis pathogens up to 5 orders of magnitude, effectively treating the biofilm-induced periodontitis. © 2023 Acta Materialia Inc.
DOI	10.1016/j.actbio.2023.09.014
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Indexed By	sci ; ei
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Document Type	期刊论文
Identifier	http://ir.ciomp.ac.cn/handle/181722/67424
Collection	中国科学院长春光学精密机械与物理研究所
Recommended Citation GB/T 7714	X. Dai, Y. Liu, F. Meng, Q. Li, F. Wu, J. Yuan, H. Chen, H. Lv, Y. Zhou and Y. Chang. Amplification of oxidative damage using near-infrared II-mediated photothermal/thermocatalytic effects for periodontitis treatment[J]. Acta Biomaterialia,2023,171:519-531.
APA	X. Dai, Y. Liu, F. Meng, Q. Li, F. Wu, J. Yuan, H. Chen, H. Lv, Y. Zhou and Y. Chang.(2023).Amplification of oxidative damage using near-infrared II-mediated photothermal/thermocatalytic effects for periodontitis treatment.Acta Biomaterialia,171,519-531.
MLA	X. Dai, Y. Liu, F. Meng, Q. Li, F. Wu, J. Yuan, H. Chen, H. Lv, Y. Zhou and Y. Chang."Amplification of oxidative damage using near-infrared II-mediated photothermal/thermocatalytic effects for periodontitis treatment".Acta Biomaterialia 171(2023):519-531.

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中国科学院长春光学精密机械与物理研究所