Bright Tm3+-based downshifting luminescence nanoprobe operating around 1800 nm for NIR-IIb and c bioimaging

doi:10.1038/s41467-023-36813-5

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	Bright Tm3+-based downshifting luminescence nanoprobe operating around 1800 nm for NIR-IIb and c bioimaging
	Y. L. Chang, H. R. Chen, X. Y. Xie, Y. Wan, Q. Q. Li, F. X. Wu, R. Yang, W. Wang and X. G. Kong
	2023
发表期刊	Nature Communications
卷号	14 期号:1 页码:9
摘要	Fluorescence imaging in the near-infrared region yields high-quality images that overcome the current depth limitations. Here, the authors report a Tm3 + -based nanoprobe for NIR-IIb/c imaging, providing references to future bioimaging beyond 1700 nm. Fluorescence bioimaging based on rare-earth-doped nanocrystals (RENCs) in the shortwave infrared (SWIR, 1000-3000 nm) region has aroused intense interest due to deeper penetration depth and clarity. However, their downshifting emission rarely shows sufficient brightness beyond 1600 nm, especially in NIR-IIc. Here, we present a class of thulium (Tm) self-sensitized RENC fluorescence probes that exhibit bright downshifting luminescence at 1600-2100 nm (NIR-IIb/c) for in vivo bioimaging. An inert shell coating minimizes surface quenching and combines strong cross-relaxation, allowing LiTmF4@LiYF4 NPs to emit these intense downshifting emissions by absorbing NIR photons at 800 nm (large Stokes shift similar to 1000 nm with a absolute quantum yield of similar to 14.16%) or 1208 nm (NIR-IIin and NIR-IIout). Furthermore, doping with Er3+ for energy trapping achieves four-wavelength NIR irradiation and bright NIR-IIb/c emission. Our results show that Tm-based NPs, as NIR-IIb/c nanoprobes with high signal-to-background ratio and clarity, open new opportunities for future applications and translation into diverse fields.
DOI	10.1038/s41467-023-36813-5
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收录类别	sci
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/67359
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	Y. L. Chang, H. R. Chen, X. Y. Xie, Y. Wan, Q. Q. Li, F. X. Wu, R. Yang, W. Wang and X. G. Kong. Bright Tm3+-based downshifting luminescence nanoprobe operating around 1800 nm for NIR-IIb and c bioimaging[J]. Nature Communications,2023,14(1):9.
APA	Y. L. Chang, H. R. Chen, X. Y. Xie, Y. Wan, Q. Q. Li, F. X. Wu, R. Yang, W. Wang and X. G. Kong.(2023).Bright Tm3+-based downshifting luminescence nanoprobe operating around 1800 nm for NIR-IIb and c bioimaging.Nature Communications,14(1),9.
MLA	Y. L. Chang, H. R. Chen, X. Y. Xie, Y. Wan, Q. Q. Li, F. X. Wu, R. Yang, W. Wang and X. G. Kong."Bright Tm3+-based downshifting luminescence nanoprobe operating around 1800 nm for NIR-IIb and c bioimaging".Nature Communications 14.1(2023):9.

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