Visible Particle Identification Using Raman Spectroscopy and Machine Learning

doi:10.1208/s12249-022-02335-4

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	Visible Particle Identification Using Raman Spectroscopy and Machine Learning
	H. Sheng; Y. P. Zhao; X. A. Long; L. W. Chen; B. Li; Y. Y. Fei; L. Mi and J. Ma
	2022
发表期刊	Aaps Pharmscitech
ISSN	1530-9932
卷号	23 期号:6 页码:12
摘要	Visible particle identification is a crucial prerequisite step for process improvement and control during the manufacturing of injectable biotherapeutic drug products. Raman spectroscopy is a technology with several advantages for particle identification including high chemical sensitivity, minimal sample manipulation, and applicability to aqueous solutions. However, considerable effort and experience are required to extract and interpret Raman spectral data. In this study, we applied machine learning algorithms to analyze Raman spectral data for visible particle identification in order to minimize expert support and improve data analysis accuracy. We manually prepared ten types of particle standard solutions to simulate the particle types typically observed during manufacturing and established a Raman spectral library with accurate peak assignments for the visible particles. Five classification algorithms were trained using visible particle Raman spectral data. All models had high prediction accuracy of >98% for all types of visible particles. Our results demonstrate that the combination of Raman spectroscopy and machine learning can provide a simple and accurate data analysis approach for visible particle identification.
DOI	10.1208/s12249-022-02335-4
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收录类别	sci
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/67232
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	H. Sheng,Y. P. Zhao,X. A. Long,et al. Visible Particle Identification Using Raman Spectroscopy and Machine Learning[J]. Aaps Pharmscitech,2022,23(6):12.
APA	H. Sheng.,Y. P. Zhao.,X. A. Long.,L. W. Chen.,B. Li.,...&L. Mi and J. Ma.(2022).Visible Particle Identification Using Raman Spectroscopy and Machine Learning.Aaps Pharmscitech,23(6),12.
MLA	H. Sheng,et al."Visible Particle Identification Using Raman Spectroscopy and Machine Learning".Aaps Pharmscitech 23.6(2022):12.

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