Research progress of single molecule biological detection methods and applications

doi:10.37188/CO.2022-0129

CIOMP OpenIR

	Research progress of single molecule biological detection methods and applications
	W.-C. Zhou; Z.-H. Li and J. Wu
	2022
发表期刊	Chinese Optics
ISSN	20971842
卷号	15 期号:5 页码:878-894
摘要	Single molecule biological detection technology is an efficient technology to understand the dynamic characteristics of various biomolecules at the single molecule level and explore their structure and function. The advantage of this technology is that it can detect the heterogeneity of free energy on a single molecule, which is beyond the traditional methods. Therefore, researchers use it to solve long-standing problems in complex biological systems, heterogeneous catalysis, biomolecular interactions, enzyme systems and conformational changes. In terms of medical detection, detecting specific information about single molecules or their interactions with biological factors is not only crucial for the early diagnosis and treatment of various diseases such as cancer, but also has great potential for real-time detection and precision medicine. The advantages of high specificity and high precision of single-molecule bioassays are used to real-time detection of single biomolecules in molecular populations, and can be combined with multiple high-throughput analysis for the precise diagnosis of clinical samples. In this paper, the principle of single molecule detection and the application of biosensing are introduced, and the detection methods and related applications are summarized. Finally, the prospect and development direction of this research direction are discussed. 2022 Editorial Office of Chinese Optics. All rights reserved.
DOI	10.37188/CO.2022-0129
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收录类别	ei
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文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/67050
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	W.-C. Zhou,Z.-H. Li and J. Wu. Research progress of single molecule biological detection methods and applications[J]. Chinese Optics,2022,15(5):878-894.
APA	W.-C. Zhou,&Z.-H. Li and J. Wu.(2022).Research progress of single molecule biological detection methods and applications.Chinese Optics,15(5),878-894.
MLA	W.-C. Zhou,et al."Research progress of single molecule biological detection methods and applications".Chinese Optics 15.5(2022):878-894.

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