Modulation of the Tumor Immune Microenvironment by Bi2Te3-Au/Pd-Based Theranostic Nanocatalysts Enables Efficient Cancer Therapy

doi:10.1002/adhm.202200809

CIOMP OpenIR

	Modulation of the Tumor Immune Microenvironment by Bi2Te3-Au/Pd-Based Theranostic Nanocatalysts Enables Efficient Cancer Therapy
	F. X. Wu; H. R. Chen; R. Q. Liu; Y. K. Suo; Q. Q. Li; Y. L. Zhang; H. G. Liu; Z. Cheng and Y. L. Chang
	2022
发表期刊	Advanced Healthcare Materials
ISSN	2192-2640
卷号	11 期号:19 页码:10
摘要	Nanozymes with multienzyme-mimicking activities have shown great potential in cancer therapy due to their ability to modulate the complex tumor microenvironment (TME). Herein, a second near-infrared (NIR-II) photothermal-nanocatalyst by decorating Bi2Te3 nanosheets with ultrasmall Au/Pd bimetallic nanoparticles (Bi2Te3-Au/Pd) to reverse the immunosuppressive TME is developed. The peroxidase (POD)-like and catalase (CAT)-like activities, and glutathione (GSH) consumption capacity of Au/Pd modulates the TME by disrupting the intracellular redox homeostasis and relieving hypoxia in the TME. Notably, the amplified oxidative stress induces the accumulation of lipid hydroperoxides (LPO) for enhanced ferroptosis. Moreover, upon NIR-II photoirradiation at 1064 nm, the localized heat generated by Bi2Te3 not only directly ablates the cancer cells but also enhances the Au/Pd-mediated catalysis-mediated cancer therapy. Furthermore, both in vitro and in vivo studies confirm that the Bi2Te3-Au/Pd nanocatalysts (BAP NCs) can effectively suppress tumor growth by inducing immunogenic cell death (ICD), and suppressing metastasis and recurrence by the synergistic treatment. Overall, this study provides a promising theranostic strategy for effective tumor inhibition.
DOI	10.1002/adhm.202200809
URL	查看原文
收录类别	sci ; ei
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/66855
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	F. X. Wu,H. R. Chen,R. Q. Liu,et al. Modulation of the Tumor Immune Microenvironment by Bi2Te3-Au/Pd-Based Theranostic Nanocatalysts Enables Efficient Cancer Therapy[J]. Advanced Healthcare Materials,2022,11(19):10.
APA	F. X. Wu.,H. R. Chen.,R. Q. Liu.,Y. K. Suo.,Q. Q. Li.,...&Z. Cheng and Y. L. Chang.(2022).Modulation of the Tumor Immune Microenvironment by Bi2Te3-Au/Pd-Based Theranostic Nanocatalysts Enables Efficient Cancer Therapy.Advanced Healthcare Materials,11(19),10.
MLA	F. X. Wu,et al."Modulation of the Tumor Immune Microenvironment by Bi2Te3-Au/Pd-Based Theranostic Nanocatalysts Enables Efficient Cancer Therapy".Advanced Healthcare Materials 11.19(2022):10.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Modulation of the Tu（8606KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载