Construction of a scalable DNA computing nano-system for large-scale and complex logical operations

doi:10.1039/d2nh00525e

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	Construction of a scalable DNA computing nano-system for large-scale and complex logical operations
	C. Y. Zhou; Y. W. Song; X. Y. Jin; B. Li and C. Y. Pang
	2022
发表期刊	Nanoscale Horizons
ISSN	2055-6756
页码	9
摘要	The predictability of Watson-Crick base pairing provides unique structural programmability to DNA, facilitating the development and application of biomolecules in biocomputing. However, in DNA-based biocomputing, the scale of operation that can be achieved by an existing reaction system is very limited. How to expand the operation range of a logic circuit and realize the integration and extensibility of circuits is always the key problem to be solved in this field. In this work, by designing a multifunctional DNA-nanostructure-based reaction platform, which can realize an output of up to 2(n) scalable fluorescence signals, combined with the construction of an input "library " and a modular distribution strategy of output signals, for the first time, we successfully performed the calculation of both square roots and cube roots of consecutive integers within a decimal number of "10 " and in each result of the operation, two digits after the decimal point are preserved ((2)root x asymptotic to M (. )ab(3)root y asymptotic to N (.) cd). We believe that the design concept presented in this work can help effectively solve the urgent problems of biological computing in terms of computational scaling, integration and scalability, and can open up new horizons for the design of new functional devices and complex computing circuits.￥internal-pdf://3757581101/Construction of a scalable DNA computing nano-.pdf￥10.1039/d2nh00525e￥https://pubs.rsc.org/en/content/articlepdf/2023/nh/d2nh00525e￥英语￥sci
DOI	10.1039/d2nh00525e
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收录类别	sci
语种	英语
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文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/66485
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	C. Y. Zhou,Y. W. Song,X. Y. Jin,et al. Construction of a scalable DNA computing nano-system for large-scale and complex logical operations[J]. Nanoscale Horizons,2022:9.
APA	C. Y. Zhou,Y. W. Song,X. Y. Jin,&B. Li and C. Y. Pang.(2022).Construction of a scalable DNA computing nano-system for large-scale and complex logical operations.Nanoscale Horizons,9.
MLA	C. Y. Zhou,et al."Construction of a scalable DNA computing nano-system for large-scale and complex logical operations".Nanoscale Horizons (2022):9.

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