Application of Dual-Enhanced Surface-Enhanced Raman Scattering Probe Technology in the Diagnosis of Tumor Cells in Vitro

doi:10.3390/molecules27113582

CIOMP OpenIR

	Application of Dual-Enhanced Surface-Enhanced Raman Scattering Probe Technology in the Diagnosis of Tumor Cells in Vitro
	Y. P. Zhao; Y. W. Kong; L. W. Chen; H. Sheng; Y. Y. Fei; L. Mi; B. Li and J. Ma
	2022
Source Publication	Molecules
Volume	27 Issue:11 Pages:10
Abstract	With the development of precision medicine, antigen/antibody-targeted therapy has brought great hope to tumor patients; however, the migration of tumor cells, especially a small number of cells flowing into blood or other tissues, remains a clinical challenge. In particular, it is difficult to use functional gold nanomaterials for targeted clinical tumor diagnosis while simultaneously obtaining stable and highly sensitive Raman signals. Therefore, we developed a detection method for functional Au Nanostars (AuNSs) with dual signal enhancement that can specifically track location and obtain high-intensity surface-enhanced Raman scattering (SERS) signals. First, AuNSs with specific optical properties were synthesized and functionalized. The Raman dye 4-mercapto-hydroxybenzoic acid and polyethylene glycol were coupled with the tumor marker, epidermal growth factor receptor, to obtain the targeted SERS probes. In addition, a detection chip was prepared for Raman detection with physical enhancement, exhibiting a 40-times higher signal intensity than that of quartz glass. This study combines physical enhancement and SERS enhancement technologies to achieve dual enhancement, enabling the detection of a highly sensitive and stable Raman signal; this has potential clinical value for antigen/antibody-targeted tumor diagnosis and treatment.
DOI	10.3390/molecules27113582
URL	查看原文
Indexed By	sci
Language	英语
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Document Type	期刊论文
Identifier	http://ir.ciomp.ac.cn/handle/181722/66424
Collection	中国科学院长春光学精密机械与物理研究所
Recommended Citation GB/T 7714	Y. P. Zhao,Y. W. Kong,L. W. Chen,et al. Application of Dual-Enhanced Surface-Enhanced Raman Scattering Probe Technology in the Diagnosis of Tumor Cells in Vitro[J]. Molecules,2022,27(11):10.
APA	Y. P. Zhao.,Y. W. Kong.,L. W. Chen.,H. Sheng.,Y. Y. Fei.,...&B. Li and J. Ma.(2022).Application of Dual-Enhanced Surface-Enhanced Raman Scattering Probe Technology in the Diagnosis of Tumor Cells in Vitro.Molecules,27(11),10.
MLA	Y. P. Zhao,et al."Application of Dual-Enhanced Surface-Enhanced Raman Scattering Probe Technology in the Diagnosis of Tumor Cells in Vitro".Molecules 27.11(2022):10.

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中国科学院长春光学精密机械与物理研究所