AIE-active Ir(III) complexes functionalised with a cationic Schiff base ligand: synthesis, photophysical properties and applications in photodynamic therapy

doi:10.1039/d2dt02960j

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	AIE-active Ir(III) complexes functionalised with a cationic Schiff base ligand: synthesis, photophysical properties and applications in photodynamic therapy
	S. N. Liu; J. H. Han; W. J. Wang; Y. L. Chang; R. L. Wang; Z. W. Wang; G. Z. Li; D. X. Zhu and M. R. Bryce
	2022
发表期刊	Dalton Transactions
ISSN	1477-9226
卷号	51 期号:42 页码:16119-16125
摘要	Photodynamic therapy (PDT) is a promising cancer treatment method. Traditional small-molecule photosensitizers (PSs) suffer from low intersystem crossing (ISC) ability and aggregation-caused quenching (ACQ), which adversely affects the luminous efficiency and singlet oxygen (O-1(2)) yield of PSs in the aggregated state. Ir(III) complexes are promising PSs with long excited-state lifetime, good photophysical and photochemical properties and large Stokes shifts. Aggregation-induced emission (AIE) characteristics could reduce the nonradiative recombination and improve the ISC ability of excited states through the restriction of the intramolecular motions in aggregated states. Accordingly, two AIE-active Ir(III) complexes Ir-1-N+ and Ir-2-N+ were successfully designed and obtained based on Schiff base ligands. Experimental results showed that Ir-1-N+ and Ir-2-N+ have good photophysical properties and the corresponding nanoparticles (NPs) have good water solubility and O-1(2) generation ability. Notably, Ir-2-N+ NPs can be efficiently taken up by mouse breast cancer cells (4T1 cells) with good biocompatibility, low dark toxicity and excellent phototoxicity. This work demonstrates a versatile strategy for exploiting efficient transition metal PSs with a cationic ligand in PDT.
DOI	10.1039/d2dt02960j
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收录类别	sci ; ei
语种	英语
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文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/66398
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	S. N. Liu,J. H. Han,W. J. Wang,et al. AIE-active Ir(III) complexes functionalised with a cationic Schiff base ligand: synthesis, photophysical properties and applications in photodynamic therapy[J]. Dalton Transactions,2022,51(42):16119-16125.
APA	S. N. Liu.,J. H. Han.,W. J. Wang.,Y. L. Chang.,R. L. Wang.,...&D. X. Zhu and M. R. Bryce.(2022).AIE-active Ir(III) complexes functionalised with a cationic Schiff base ligand: synthesis, photophysical properties and applications in photodynamic therapy.Dalton Transactions,51(42),16119-16125.
MLA	S. N. Liu,et al."AIE-active Ir(III) complexes functionalised with a cationic Schiff base ligand: synthesis, photophysical properties and applications in photodynamic therapy".Dalton Transactions 51.42(2022):16119-16125.

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