Smart-phone phase contrast microscope with a singlet lens and deep learning

doi:10.1016/j.optlastec.2020.106900

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	Smart-phone phase contrast microscope with a singlet lens and deep learning
	Y. Bian; Y. Jiang; Y. Huang; X. Yang; W. Deng; H. Shen; R. Shen and C. Kuang
	2021
发表期刊	Optics and Laser Technology
ISSN	303992
卷号	139
摘要	Amounts of cost-effective biological observing and detecting instruments are needed in biology and medical applications. In these demands, a low-cost, portable microscope with light-weight and tele-communication, is very attractive in the resource-limit area. In this manuscript, a portable singlet phase contrast microscope based on smart-phones are proposed. In the optics hardware, an external singlet lens is designed and closely attached before the rear cameras of a smart-phone, which constructs the imaging part of a simplified microscope. And a circular oblique illumination is adopted. In the computational imaging part, the in-focus images recorded by the smart-phone are virtually enhanced and style-transferred to phase contrast images by deep learning methods. Through pairs of experimental image data, we train the deep learning network and demonstrate the effectiveness of this virtual phase contrast imaging approach using multiple samples, e.g., unstained/transparent tumor tissue pathological slide, and H&E (Hematoxylin and Eosin) stained tumor tissue pathological slide. Our results provide a powerful example of low-cost portable phase contrast microscope with high-speed tele-communication abilities in the 5G + mobile internet era. 2020
DOI	10.1016/j.optlastec.2020.106900
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收录类别	SCI ; EI
引用统计
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/65639
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	Y. Bian,Y. Jiang,Y. Huang,et al. Smart-phone phase contrast microscope with a singlet lens and deep learning[J]. Optics and Laser Technology,2021,139.
APA	Y. Bian.,Y. Jiang.,Y. Huang.,X. Yang.,W. Deng.,...&R. Shen and C. Kuang.(2021).Smart-phone phase contrast microscope with a singlet lens and deep learning.Optics and Laser Technology,139.
MLA	Y. Bian,et al."Smart-phone phase contrast microscope with a singlet lens and deep learning".Optics and Laser Technology 139(2021).

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