Hybrid Nanoplatform: Enabling a Precise Antitumor Strategy via Dual-Modal Imaging-Guided Photodynamic/Chemo-/Immunosynergistic Therapy

doi:10.1021/acsnano.1c09635

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	Hybrid Nanoplatform: Enabling a Precise Antitumor Strategy via Dual-Modal Imaging-Guided Photodynamic/Chemo-/Immunosynergistic Therapy
	H. Chen; F. Wu; X. Xie; W. Wang; Q. Li; L. Tu; B. Li; X. Kong and Y. Chang
	2021
Source Publication	ACS Nano
ISSN	19360851
Volume	15 Issue:12 Pages:20643-20655
Abstract	Photodynamic therapy (PDT) has been widely used in tumor therapy due to its high spatial-temporal control and noninvasiveness. However, its clinical application is limited by weak efficacy, shallow tissue penetration, and phototoxicity. Herein, a facile theranostic nanoplatform based on photoswitchable lanthanide-doped nanoparticles was designed. Typically, these nanoparticles had UV-blue and 1525 nm emission upon 980 nm excitation and 1525 nm emission upon 800 nm excitation. We further used these nanoparticles for achieving real-time near-infrared (NIR)-IIb imaging (800 nm) with a high signal-to-noise ratio and imaging-guided PDT (980 nm). Moreover, such a photoswitchable nanoplatform capping with pH-sensitive calcium phosphate for coloading doxorubicin (a chemotherapeutic immunogenic cell death [ICD] inducer) and paramagnetic Mn2+ ions enhances T1-magnetic resonance imaging in the tumor microenvironment. Our results suggest that this theranostic nanoplatform could not only kill tumor cells directly through dual-modal image-guided PDT/chemotherapy but also inhibit distant tumor and lung metastasis through ICD. Therefore, it has great potential for clinical application. 2021 American Chemical Society.
DOI	10.1021/acsnano.1c09635
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Indexed By	SCI ; EI
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Document Type	期刊论文
Identifier	http://ir.ciomp.ac.cn/handle/181722/65308
Collection	中国科学院长春光学精密机械与物理研究所
Recommended Citation GB/T 7714	H. Chen,F. Wu,X. Xie,et al. Hybrid Nanoplatform: Enabling a Precise Antitumor Strategy via Dual-Modal Imaging-Guided Photodynamic/Chemo-/Immunosynergistic Therapy[J]. ACS Nano,2021,15(12):20643-20655.
APA	H. Chen.,F. Wu.,X. Xie.,W. Wang.,Q. Li.,...&X. Kong and Y. Chang.(2021).Hybrid Nanoplatform: Enabling a Precise Antitumor Strategy via Dual-Modal Imaging-Guided Photodynamic/Chemo-/Immunosynergistic Therapy.ACS Nano,15(12),20643-20655.
MLA	H. Chen,et al."Hybrid Nanoplatform: Enabling a Precise Antitumor Strategy via Dual-Modal Imaging-Guided Photodynamic/Chemo-/Immunosynergistic Therapy".ACS Nano 15.12(2021):20643-20655.

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中国科学院长春光学精密机械与物理研究所