Er3+ self-sensitized nanoprobes with enhanced 1525 nm downshifting emission for NIR-IIb in vivo bio-imaging

doi:10.1039/d0tb02728f

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	Er3+ self-sensitized nanoprobes with enhanced 1525 nm downshifting emission for NIR-IIb in vivo bio-imaging
	W. Wang; Z. Feng; B. Li; Y. L. Chang; X. Li; X. Yan; R. Z. Chen; X. M. Yu; H. Y. Zhao; G. Y. Lu; X. G. Kong; J. Qian and X. M. Liu
	2021
Source Publication	Journal of Materials Chemistry B
ISSN	2050-750X
Volume	9 Issue:12 Pages:2899-2908
Abstract	Traditional sensitizer (Yb3+ or Nd3+) and activator (Er3+) co-doped lanthanide-based nanoprobes possessing emission of Er3+ at 1525 nm have attracted much attention in NIR-IIb bio-imaging. However, the 1525 nm fluorescence efficiency was not high enough in such co-doped systems due to the serious back energy transfer from the activator to the sensitizer, resulting in a lot of excitation energy loss. Herein, we have designed an efficient NIR-IIb nanoprobe Er3+ self-sensitized NaErF4:0.5%Tm3+@NaLuF4, where substantially all the excitation energy could contribute to Er3+ ions and most energy transfer processes were confined among Er3+ ions, avoiding the energy dissipation by heterogeneous sensitizer ions. The influence of the types of epitaxial heterogeneous shells, the doping effect and optimal doping concentration of Tm3+ ions, as well as the critical shell thickness for obtaining the surface quenching-assisted downshifting emission are systematically investigated to acquire the most efficient 1525 nm luminescence under 800 nm excitation. The quantum yield in the 1500-1700 nm region reached 13.92%, enabling high-resolution through-skull cerebrovascular microscopy imaging and large-depth in vivo physiological dynamic imaging with an extremely low excitation powder density of 35 mW cm(-2). The designed nanoprobe can be potentially used for brain science research and clinical diagnosis.
DOI	10.1039/d0tb02728f
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Indexed By	SCI
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Document Type	期刊论文
Identifier	http://ir.ciomp.ac.cn/handle/181722/65226
Collection	中国科学院长春光学精密机械与物理研究所
Recommended Citation GB/T 7714	W. Wang,Z. Feng,B. Li,et al. Er3+ self-sensitized nanoprobes with enhanced 1525 nm downshifting emission for NIR-IIb in vivo bio-imaging[J]. Journal of Materials Chemistry B,2021,9(12):2899-2908.
APA	W. Wang.,Z. Feng.,B. Li.,Y. L. Chang.,X. Li.,...&J. Qian and X. M. Liu.(2021).Er3+ self-sensitized nanoprobes with enhanced 1525 nm downshifting emission for NIR-IIb in vivo bio-imaging.Journal of Materials Chemistry B,9(12),2899-2908.
MLA	W. Wang,et al."Er3+ self-sensitized nanoprobes with enhanced 1525 nm downshifting emission for NIR-IIb in vivo bio-imaging".Journal of Materials Chemistry B 9.12(2021):2899-2908.

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中国科学院长春光学精密机械与物理研究所