Deep learning virtual colorization overcoming chromatic aberrations in singlet lens microscopy

doi:10.1063/5.0039206

CIOMP OpenIR

	Deep learning virtual colorization overcoming chromatic aberrations in singlet lens microscopy
	Y. Bian; Y. Jiang; Y. Huang; X. Yang; W. Deng; H. Shen; R. Shen and C. Kuang
	2021
发表期刊	APL Photonics
ISSN	23780967
卷号	6 期号:3
摘要	Singlet lenses are free from precise assembling, aligning, and testing, which are helpful for the development of portable and low-cost microscopes. However, balancing the spectrum dispersion or chromatic aberrations using a singlet lens made of one material is difficult. Here, a novel method combining singlet lens microscopy and computational imaging, which is based on deep learning image-style-transfer algorithms, is proposed to overcome this problem in clinical pathological slide microscopy. In this manuscript, a singlet aspheric lens is used, which has a high cut-off frequency and linear signal properties. Enhanced by a trained deep learning network, it is easy to transfer the monochromatic gray-scale microscopy picture to a colorful microscopy picture, with only one single-shot recording by a monochromatic CMOS image sensor. By experiments, data analysis, and discussions, it is proved that our proposed virtual colorization microscope imaging method is effective for H&E stained tumor tissue slides in singlet microscopy. It is believable that the computational virtual colorization method for singlet microscopes would promote the low-cost and portable singlet microscopy development in medical pathological label staining observing (e.g., H&E staining, Gram staining, and fluorescent labeling) biomedical research. 2021 Author(s.
DOI	10.1063/5.0039206
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收录类别	SCI ; EI
引用统计
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/65127
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	Y. Bian,Y. Jiang,Y. Huang,et al. Deep learning virtual colorization overcoming chromatic aberrations in singlet lens microscopy[J]. APL Photonics,2021,6(3).
APA	Y. Bian.,Y. Jiang.,Y. Huang.,X. Yang.,W. Deng.,...&R. Shen and C. Kuang.(2021).Deep learning virtual colorization overcoming chromatic aberrations in singlet lens microscopy.APL Photonics,6(3).
MLA	Y. Bian,et al."Deep learning virtual colorization overcoming chromatic aberrations in singlet lens microscopy".APL Photonics 6.3(2021).

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