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Ten-Input Cube Root Logic Computation with Rational Designed DNA Nanoswitches Coupled with DNA Strand Displacement Process
C. Y. Zhou,H. M. Geng,P. F. Wang and C. L. Guo
2020
发表期刊Acs Applied Materials & Interfaces
ISSN1944-8244
卷号12期号:2页码:2601-2606
摘要The predictability of Watson-Crick base pairing provides a unique structural programmability to DNAs, promoting a facile design of bimolecular reactions that perform computation. However, most of the current architectures could only implement limited logical circuits and are incapable of handling more complex mathematical operations, thus limiting computing devices from advancing to the next-stage functional complexity. Here, by designing a multifunctional DNA-based reaction platform coupled with multiple fluorescent substrates as output reporters, we construct, for the first time, a logic circuit that can compute the cube root of a 10-bit binary number (within the decimal number 1000). This relatively large-scale logic system with 10 inputs and four outputs showcases the power of DNAs in the field of biological computing and will potentially open up a new horizon for designing novel functional devices and complex computing circuits and bringing breakthroughs in biocomputing.
DOI10.1021/acsami.9b15180
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收录类别SCI ; EI
语种英语
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文献类型期刊论文
条目标识符http://ir.ciomp.ac.cn/handle/181722/64947
专题中国科学院长春光学精密机械与物理研究所
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C. Y. Zhou,H. M. Geng,P. F. Wang and C. L. Guo. Ten-Input Cube Root Logic Computation with Rational Designed DNA Nanoswitches Coupled with DNA Strand Displacement Process[J]. Acs Applied Materials & Interfaces,2020,12(2):2601-2606.
APA C. Y. Zhou,H. M. Geng,P. F. Wang and C. L. Guo.(2020).Ten-Input Cube Root Logic Computation with Rational Designed DNA Nanoswitches Coupled with DNA Strand Displacement Process.Acs Applied Materials & Interfaces,12(2),2601-2606.
MLA C. Y. Zhou,H. M. Geng,P. F. Wang and C. L. Guo."Ten-Input Cube Root Logic Computation with Rational Designed DNA Nanoswitches Coupled with DNA Strand Displacement Process".Acs Applied Materials & Interfaces 12.2(2020):2601-2606.
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