中国科学院长春光学精密机械与物理研究所

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	Polyphotosensitizer nanogels for GSH-responsive histone deacetylase inhibitors delivery and enhanced cancer photodynamic therapy
	N. Liu,H. S. Liu,H. R. Chen,G. Wang,H. L. Teng and Y. L. Chang
	2020
发表期刊	Colloids and Surfaces B-Biointerfaces
ISSN	0927-7765
卷号	188页码:11
摘要	Photodynamic therapy (PDT) is one of the non-invasive and selective treatment methodologies for cancer. However, many highly efficient photosensitizers (PSs) are usually low physiological solubility, limited bioavailability and tending aggregation, impeding the effectiveness of PDT, as well as cancer resistance of PDT further reduce its therapeutic effect. Though some smart delivery systems have been developed, the problem of photosensitizer leakage/release has not been completely solved. Herein, we developed a smart therapeutic nanoplatform based on polyphotosensitizer nanogel as novel nanophotosensitizers and drug carriers. Moreover, by loading of histone deacetylase inhibitors (SAHA), it allows for enhanced synergistic therapy strategy of prostate cancer via inhibiting HIF-1 alpha and VEGF pathways of cancer cells involved in PDT resistance. Our study presents the well-designed nanoplatform of nanogel-Ce6, which could serve as a photodynamic agent without Ce6 molecules release in the responsive environment, offering the potential to encapsulate diverse functional components for smart drug release and imaging-guided combination therapy in vitro and in vivo.
DOI	10.1016/j.colsurfb.2019.110753
URL	查看原文
收录类别	SCI ; EI
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/64800
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	N. Liu,H. S. Liu,H. R. Chen,G. Wang,H. L. Teng and Y. L. Chang. Polyphotosensitizer nanogels for GSH-responsive histone deacetylase inhibitors delivery and enhanced cancer photodynamic therapy[J]. Colloids and Surfaces B-Biointerfaces,2020,188:11.
APA	N. Liu,H. S. Liu,H. R. Chen,G. Wang,H. L. Teng and Y. L. Chang.(2020).Polyphotosensitizer nanogels for GSH-responsive histone deacetylase inhibitors delivery and enhanced cancer photodynamic therapy.Colloids and Surfaces B-Biointerfaces,188,11.
MLA	N. Liu,H. S. Liu,H. R. Chen,G. Wang,H. L. Teng and Y. L. Chang."Polyphotosensitizer nanogels for GSH-responsive histone deacetylase inhibitors delivery and enhanced cancer photodynamic therapy".Colloids and Surfaces B-Biointerfaces 188(2020):11.

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