Optimization of leakage detection system for vials based on two-line tunable diode laser absorption spectroscopy

doi:10.1016/j.saa.2020.118194

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	Optimization of leakage detection system for vials based on two-line tunable diode laser absorption spectroscopy
	Y. X. Zhang,W. W. Wu,H. N. Yang,C. L. Li,J. Tao and R. F. Kan
	2020
发表期刊	Spectrochimica Acta Part a-Molecular and Biomolecular Spectroscopy
ISSN	1386-1425
卷号	233 页码:6
摘要	The leakage detection system of vials based on two-line water-vapor tunable diode laser absorption spectroscopy (TDLAS) developed in our previous work was first employed to investigate the instantaneous leakage processes of sealed vials. It showed that the leakage states of the vials with medicines cannot be accurately determined in a short time after the opening. Therefore, an optimized system was developed with two-line oxygen TDLAS method by the measurement of defined oxygen leakage coefficient, and it was then utilized to study the instantaneous leakage processes of sealed vials. It revealed that when the stoppers of the sealed vials were opened, the oxygen leakage coefficients increased immediately and then reach stable. It indicated that the optimized system was not affected by the water absorption of medicines. Furthermore, 15 vials with known leakage states were measured. It showed that the oxygen leakage coefficients of fully-open vials were obviously larger than that of sealed vials, and the maximum standard deviation of oxygen leakage coefficients for ten measurements of a single vial was 0.03%.The sealed vials with different leakage degrees were then investigated by inserting the needles with different sizes (05/1/2/3.5 min) into the vials. It revealed that the time required for the oxygen leakage coefficients to reach stable was shorter for the vials with larger leakage degree, i.e., larger needle size inserted. It showed that non-invasive, fast response and high-accuracy leakage detection of vials can be realized by the optimized system. (C) 2020 Elsevier B.V. All rights reserved.
DOI	10.1016/j.saa.2020.118194
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收录类别	SCI
语种	英语
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文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/64767
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	Y. X. Zhang,W. W. Wu,H. N. Yang,C. L. Li,J. Tao and R. F. Kan. Optimization of leakage detection system for vials based on two-line tunable diode laser absorption spectroscopy[J]. Spectrochimica Acta Part a-Molecular and Biomolecular Spectroscopy,2020,233:6.
APA	Y. X. Zhang,W. W. Wu,H. N. Yang,C. L. Li,J. Tao and R. F. Kan.(2020).Optimization of leakage detection system for vials based on two-line tunable diode laser absorption spectroscopy.Spectrochimica Acta Part a-Molecular and Biomolecular Spectroscopy,233,6.
MLA	Y. X. Zhang,W. W. Wu,H. N. Yang,C. L. Li,J. Tao and R. F. Kan."Optimization of leakage detection system for vials based on two-line tunable diode laser absorption spectroscopy".Spectrochimica Acta Part a-Molecular and Biomolecular Spectroscopy 233(2020):6.

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