Graphene-based ultrasensitive optical microfluidic sensor for the real-time and label-free monitoring of simulated arterial blood flow

doi:10.1364/oe.392993

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	Graphene-based ultrasensitive optical microfluidic sensor for the real-time and label-free monitoring of simulated arterial blood flow
	T. G. Wu,J. F. Shen,Z. W. Li,T. T. Zou,W. Xin,F. Xing,F. Zhang,Z. S. Man and S. G. Fu
	2020
发表期刊	Optics Express
ISSN	1094-4087
卷号	28 期号:11 页码:16594-16604
摘要	Highly sensitive, real-time and label-free sensing of liquid flow in microfluidic environments remains challenging. Here, by growing high-quality graphene directly on a glass substrate, we designed a microfluidic-integrated graphene-based flow sensor (GFS) capable of detecting complex, weak, and transient flow velocity and pressure signals in a microfluidic environment. This device was used to study weak and transient liquid flows, especially blood flow, which is closely related to heart and artery functions. By simulating cardiac peristalsis and arterial flow using peristaltic pumps and microfluidic systems, we monitored simulated arterial blood flow. This ultrasensitive graphene-based flow sensor accurately detected a flow velocity limit as low as 0.7 mm/s, a pumping frequency range of 0.04 Hz to 2.5 Hz, and a pressure range from 0.6 kPa to 14 kPa. By measuring the blood flow velocities and pressures, pathological blood flow signals were distinguished and captured by the corresponding flow velocities or pressures, which can reflect vascular occlusion and heart functions. This sensor may be used for the real-time and label-free monitoring of patients' basic vital signs using their blood flow and provide a possible new method for the care of critically ill patients. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
DOI	10.1364/oe.392993
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收录类别	SCI ; EI
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/64544
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	T. G. Wu,J. F. Shen,Z. W. Li,T. T. Zou,W. Xin,F. Xing,F. Zhang,Z. S. Man and S. G. Fu. Graphene-based ultrasensitive optical microfluidic sensor for the real-time and label-free monitoring of simulated arterial blood flow[J]. Optics Express,2020,28(11):16594-16604.
APA	T. G. Wu,J. F. Shen,Z. W. Li,T. T. Zou,W. Xin,F. Xing,F. Zhang,Z. S. Man and S. G. Fu.(2020).Graphene-based ultrasensitive optical microfluidic sensor for the real-time and label-free monitoring of simulated arterial blood flow.Optics Express,28(11),16594-16604.
MLA	T. G. Wu,J. F. Shen,Z. W. Li,T. T. Zou,W. Xin,F. Xing,F. Zhang,Z. S. Man and S. G. Fu."Graphene-based ultrasensitive optical microfluidic sensor for the real-time and label-free monitoring of simulated arterial blood flow".Optics Express 28.11(2020):16594-16604.

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