Carbon Dots Induce Epithelial-Mesenchymal Transition for Promoting Cutaneous Wound Healing via Activation of TGF-beta/p38/Snail Pathway

doi:10.1002/adfm.202004886

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	Carbon Dots Induce Epithelial-Mesenchymal Transition for Promoting Cutaneous Wound Healing via Activation of TGF-beta/p38/Snail Pathway
	Z. L. Wang,L. L. Liu,W. H. Bu,M. D. Zheng,N. Q. Jin,K. Zhang,X. W. Xu,D. Zhou,B. Yang and H. C. Sun
	2020
发表期刊	Advanced Functional Materials
ISSN	1616-301X
卷号	30 期号:43 页码:16
摘要	Skin lesions, as a relatively common clinical manifestation, not only damage the skin's barrier function, but also affect the skin's ability to feel temperature, pain and touch. However, a highly efficient method to restore the morphology and function of damaged skin remains an unmet goal. In this work, carbon dots (CDots) with excellent biocompatibility are synthesized via microwave-assisted heating ascorbic acid and polyethyleneimine. The synthesized CDots can induce the epithelial-mesenchymal transition (EMT) process by activating transforming growth factor-beta/p-38 mitogen-activated kinase/Snail signaling pathway, leading to an increase of cell motility. Further, by assessing a series of in vivo wound healing assays and histological examinations, it is demonstrated that CDots can accelerate the migration of epithelial cells in the full-thickness cutaneous wounds through EMT. As a result, a rapid re-epithelialization covers the granulation tissue and epidermal barrier formed, leading to a block of the external stimuli, reduction of the inflammatory reaction and the granulation tissue area, and finally the promotion of the wound healing with fewer scars.
DOI	10.1002/adfm.202004886
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收录类别	SCI
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/64350
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	Z. L. Wang,L. L. Liu,W. H. Bu,M. D. Zheng,N. Q. Jin,K. Zhang,X. W. Xu,D. Zhou,B. Yang and H. C. Sun. Carbon Dots Induce Epithelial-Mesenchymal Transition for Promoting Cutaneous Wound Healing via Activation of TGF-beta/p38/Snail Pathway[J]. Advanced Functional Materials,2020,30(43):16.
APA	Z. L. Wang,L. L. Liu,W. H. Bu,M. D. Zheng,N. Q. Jin,K. Zhang,X. W. Xu,D. Zhou,B. Yang and H. C. Sun.(2020).Carbon Dots Induce Epithelial-Mesenchymal Transition for Promoting Cutaneous Wound Healing via Activation of TGF-beta/p38/Snail Pathway.Advanced Functional Materials,30(43),16.
MLA	Z. L. Wang,L. L. Liu,W. H. Bu,M. D. Zheng,N. Q. Jin,K. Zhang,X. W. Xu,D. Zhou,B. Yang and H. C. Sun."Carbon Dots Induce Epithelial-Mesenchymal Transition for Promoting Cutaneous Wound Healing via Activation of TGF-beta/p38/Snail Pathway".Advanced Functional Materials 30.43(2020):16.

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