In Vivo Tumor Photoacoustic Imaging and Photothermal Therapy Based on Supra-(Carbon Nanodots)

doi:10.1002/adhm.201800995

	In Vivo Tumor Photoacoustic Imaging and Photothermal Therapy Based on Supra-(Carbon Nanodots)
	G.Y.Xu; X.Bao; J.Q.Chen; B.H.Zhang; D.Li; D.Zhou; X.Y.Wang
	2019
发表期刊	Advanced Healthcare Materials
ISSN	2192-2640
卷号	8 期号:2 页码:7
摘要	Carbon nanodots (CNDs) with high photothermal conversion efficiency are considered as emerging nanomaterials for advanced biomedical applications attributing to their high biocompatibility, low-cost, and unique photophysical properties. In previous work, supra-CNDs are synthesized exhibiting high absorption in the near-infrared (NIR) region and good NIR photothermal conversion performance. In this work, supra-CNDs are explored as a photothermal agent for photothermal therapy (PTT) and a contrast agent for photoacoustic (PA) imaging, respectively. As a result, in vivo tumor PTT is realized under 655 nm laser irradiation via intratumor injecting supra-CNDs. In vivo PA imaging reveals that supra-CNDs can accumulate in the tumor tissue via the blood circulation after intravenous injection. Moreover, in vivo PTT is conducted after intravenous injection and subsequent tumor accumulation of supra-CNDs, and the lives of mice are prolonged due to the tumor growth inhibition after PTT. These attractive properties indicate that the supra-CNDs can be used as biomedical agents for PA imaging and tumor therapy.
关键词	photoacoustic imaging,photothermal therapy,supracarbon nanodots,graphene quantum dots,emissive carbon dots
DOI	10.1002/adhm.201800995
收录类别	SCI
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/63483
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	G.Y.Xu,X.Bao,J.Q.Chen,et al. In Vivo Tumor Photoacoustic Imaging and Photothermal Therapy Based on Supra-(Carbon Nanodots)[J]. Advanced Healthcare Materials,2019,8(2):7.
APA	G.Y.Xu.,X.Bao.,J.Q.Chen.,B.H.Zhang.,D.Li.,...&X.Y.Wang.(2019).In Vivo Tumor Photoacoustic Imaging and Photothermal Therapy Based on Supra-(Carbon Nanodots).Advanced Healthcare Materials,8(2),7.
MLA	G.Y.Xu,et al."In Vivo Tumor Photoacoustic Imaging and Photothermal Therapy Based on Supra-(Carbon Nanodots)".Advanced Healthcare Materials 8.2(2019):7.