Assembly of upconversion nanophotosensitizer in vivo to achieve scatheless real-time imaging and selective photodynamic therapy

doi:10.1016/j.biomaterials.2019.02.015

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	Assembly of upconversion nanophotosensitizer in vivo to achieve scatheless real-time imaging and selective photodynamic therapy
	Y.S.Feng; Y.N.Wu; J.Zuo; L.P.Tu; I.Que; Y.L.Chang; L.J.Cruz
	2019
发表期刊	Biomaterials
ISSN	0142-9612
卷号	201 页码:33-41
摘要	A perfect "off" to "on" switch of the therapeutic function is very important to minimize the phototoxicity of nanoplatforms assisted imaging-guided photodynamic therapy (PDT) of cancer. Current approaches rely on preloaded photosensitizers, where the off/on state of PDT is regulated by the sensitizing light of photosensitizers. However, the photoactivities inevitably occur when imaging/diagnosis or exposure to sunlight, etc. These pre-loading approaches will cause the damage to normal cells and the photosensitivity to the skin. Taking upconversion photodynamic therapy as an example we report here a biorthogonal chemistry solution to circumvent this problem. The luminescence upconversion nanoparticles (UCNPs) are anchored with one handle of click reaction and targeting entity, these nanoplatforms enable the imaging/labelling/tracking, especially for imaging-guided surgery. Once they are targeted, the photosensitizers armed with the other match handle will be injected in situ and click reaction will occur between the two handles to link the photosensitizers closely with the targeted nanoplatforms in a very short time, enabling the PDT function of the nanoplatforms. Proof of principle has been demonstrated in vitro and in vivo. This approach can be readily extended to chemotherapy, radiotherapy, etc. to overcome the side effect of these therapies of cancers.
关键词	Bioorthogonal chemistry,Upconversion luminescence,Real-time imaging,Switchable photodynamic therapy,click chemistry
DOI	10.1016/j.biomaterials.2019.02.015
URL	查看原文
收录类别	SCI ; EI
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/63391
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	Y.S.Feng,Y.N.Wu,J.Zuo,et al. Assembly of upconversion nanophotosensitizer in vivo to achieve scatheless real-time imaging and selective photodynamic therapy[J]. Biomaterials,2019,201:33-41.
APA	Y.S.Feng.,Y.N.Wu.,J.Zuo.,L.P.Tu.,I.Que.,...&L.J.Cruz.(2019).Assembly of upconversion nanophotosensitizer in vivo to achieve scatheless real-time imaging and selective photodynamic therapy.Biomaterials,201,33-41.
MLA	Y.S.Feng,et al."Assembly of upconversion nanophotosensitizer in vivo to achieve scatheless real-time imaging and selective photodynamic therapy".Biomaterials 201(2019):33-41.

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