DNA-based digital comparator systems constructed by multifunctional nanoswitches

doi:10.1039/c9nr08216f

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	DNA-based digital comparator systems constructed by multifunctional nanoswitches
	H.M.Geng; C.Y.Zhou; C.L.Guo
	2019
发表期刊	Nanoscale
ISSN	2040-3364
卷号	11 期号:45 页码:21856-21866
摘要	In this paper, we propose a strategy involving coupling DNA structural nanoswitches with toehold mediated strand displacement for constructing novel DNA-based digital comparator (DC) logic systems, which are a basic part of traditional electronic computers and can compare whether two or more input numbers are equal. However, when the number of DC inputs is increased to a certain level, the speed and quality of the computing circuit can be affected because of the limitations of conventional electronic computers when it comes to handling large-scale quantities of data. To solve this problem, in this work, we introduce a multi-input to multi-output DNA switch-based platform that can enable complex DC logical comparison. These multifunctional DNA-based switches, each including two hairpin-shaped molecular beacons and a G4/NMM complex, were used as platforms for the step-by-step realization of 2-3 DC, 3-3 DC, and 4-3 DC logic operations. Also, experiments were designed to further verify the excellent selectivity, achieving single-base mismatch operations with the digital comparator. Based on our design, comparators (">", "<" and "=") can be realized. Our prototype can inspire new designs and have intelligent digital comparator and in-field applications.
关键词	enzyme-free,strand displacement,logic operations,universal platform,nucleic-acids
DOI	10.1039/c9nr08216f
URL	查看原文
收录类别	SCI ; EI
语种	英语
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/63365
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	H.M.Geng,C.Y.Zhou,C.L.Guo. DNA-based digital comparator systems constructed by multifunctional nanoswitches[J]. Nanoscale,2019,11(45):21856-21866.
APA	H.M.Geng,C.Y.Zhou,&C.L.Guo.(2019).DNA-based digital comparator systems constructed by multifunctional nanoswitches.Nanoscale,11(45),21856-21866.
MLA	H.M.Geng,et al."DNA-based digital comparator systems constructed by multifunctional nanoswitches".Nanoscale 11.45(2019):21856-21866.

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