Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer

doi:10.1002/cam4.1938

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	Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer
	Y.Liu; J.Li; Z.F.Ma; J.Zhang; Y.Z.Wang; Z.H.Yu; X.Lin
	2019
发表期刊	Cancer Medicine
ISSN	2045-7634
卷号	8 期号:2 页码:729-741
摘要	Protein Kinase D (PKD) family contains PKD1, PKD2, and PKD3 in human. Compared to consistent tumor-suppressive functions of PKD1 in breast cancer, how PKD2/3 functions in breast cancer are not fully understood. In the current study, we found that PKD2 and PKD3 but not PKD1 were preferentially overexpressed in breast cancer and involved in regulating cell proliferation and metastasis. Integrated phosphoproteome, transcriptome, and interactome showed that PKD2 was associated with multiple cancer-related pathways, including adherent junction, regulation of actin cytoskeleton, and cell cycle-related pathways. ELAVL1 was identified as a common hub-node in networks of PKD2/3-regulated phosphoproteins and genes. Silencing ELAVL1 inhibited breast cancer growth in vitro and in vivo. Direct interaction between ELAVL1 and PKD2 or PKD3 was demonstrated. Suppression of PKD2 led to ELAVL1 translocation from the cytoplasm to the nucleus without significant affecting ELAVL1 expression. Taken together, we characterized the oncogenic functions of PKD2/3 in breast cancer and their association with cancer-related pathways, which shed lights on the oncogenic roles and mechanisms of PKDs in breast cancer.
关键词	breast cancer,phosphoproteome analysis,PKD2,PKD3,transcriptome,analysis,nf-kappa-b,growth,contributes,expression,activation,networks,target,d1,Oncology
DOI	10.1002/cam4.1938
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收录类别	SCI
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/63173
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	Y.Liu,J.Li,Z.F.Ma,et al. Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer[J]. Cancer Medicine,2019,8(2):729-741.
APA	Y.Liu.,J.Li.,Z.F.Ma.,J.Zhang.,Y.Z.Wang.,...&X.Lin.(2019).Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.Cancer Medicine,8(2),729-741.
MLA	Y.Liu,et al."Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer".Cancer Medicine 8.2(2019):729-741.

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