Near- infrared light- mediated and nitric oxide- supplied nanospheres for enhanced synergistic thermo- chemotherapy

doi:10.1039/c8tb02939c

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	Near- infrared light- mediated and nitric oxide- supplied nanospheres for enhanced synergistic thermo- chemotherapy
	C.Zhang; Q.Q.Li; Y.Zhao; H.Liu; S.L.Song; Y.Q.Zhao; Q.Lin; Y.L.Chang
	2019
发表期刊	Journal of Materials Chemistry B
ISSN	2050-750X
卷号	7 期号:4 页码:548-555
摘要	Synergistic thermo-chemotherapy based multiple stimuli-responsive drug delivery systems have achieved significant improvement of cancer curative effects compared with single modality treatment. Nevertheless, the efficacy of thermo-chemotherapy is often reduced in drug-resistant tumors and the therapy method is unexpectedly associated with potential toxicity by utilizing poorly degradable materials. Here, we report a simple approach to encapsulate three drug payloads into multi-sensitive and degradable nanospheres (SDC@NS) to achieve anticancer effects. SDC@NS comprise a photothermal agent (cypate), an anticancer agent (doxorubicin), and a nitric oxide donor (SNAP) to achieve controllable drugs release in high concentration glutathione or under near-infrared light (NIR) irradiation. Hyperthermia from NIR-mediated cypate can accelerate cancer cell apoptosis in vitro and tumor tissue ablation in vivo. Furthermore, our results also confirmed that the nitric oxide-based SDC@NS showed significant cytotoxicity compared to the nitric oxide absent group (denoted as DC@NS) and an enhanced chemotherapy effect in vivo. The photothermal effect and payloads can synchronously realize cancer therapy and provide a new insight into the enhanced synergistic therapeutic effect.
关键词	multidrug-resistance,shell nanoparticles,targeted delivery,p-glycoprotein,drug-delivery,doxorubicin,cancer,therapy,release,nanoplatform,Materials Science
DOI	10.1039/c8tb02939c
URL	查看原文
收录类别	SCI ; EI
语种	英语
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/62823
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	C.Zhang,Q.Q.Li,Y.Zhao,et al. Near- infrared light- mediated and nitric oxide- supplied nanospheres for enhanced synergistic thermo- chemotherapy[J]. Journal of Materials Chemistry B,2019,7(4):548-555.
APA	C.Zhang.,Q.Q.Li.,Y.Zhao.,H.Liu.,S.L.Song.,...&Y.L.Chang.(2019).Near- infrared light- mediated and nitric oxide- supplied nanospheres for enhanced synergistic thermo- chemotherapy.Journal of Materials Chemistry B,7(4),548-555.
MLA	C.Zhang,et al."Near- infrared light- mediated and nitric oxide- supplied nanospheres for enhanced synergistic thermo- chemotherapy".Journal of Materials Chemistry B 7.4(2019):548-555.

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