An 800 nm driven NaErF4@NaLuF4 upconversion platform for multimodality imaging and photodynamic therapy

doi:10.1039/c8nr00446c

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	An 800 nm driven NaErF4@NaLuF4 upconversion platform for multimodality imaging and photodynamic therapy
	Li, Q. Q.; Li, X. D.; Zhang, L.; Zuo, J.; Zhang, Y. L.; Liu, X. M.; Tu, L. P.; Xue, B.; Chang, Y. L.; Kong, X. G.
	2018
Source Publication	Nanoscale
ISSN	2040-3364
Volume	10 Issue:26 Pages:12356-12363
Abstract	Multimodality imaging-guided therapy based on lanthanide-doped upconversion nanoparticles (UCNPs) has become a trend in cancer theranostics. However, the overheating effect of 980 nm excitation in photodynamic therapy (PDT) and the difficulties in optimizing multimodality imaging integration within a single particle are still challenges. Herein, 800 nm driven NaErF4@NaLuF4 UCNPs have been explored for optimized multimodality imaging and near-infrared (NIR) triggered PDT. Our results confirmed that the optimal similar to 5 nm shell thickness can well balance the enhancement of upconversion luminescence and the attenuation of energy transfer efficiency from Er3+ towards a photosensitizer, to achieve efficient production of singlet oxygen (O-1(2)) for PDT under 800 nm excitation. Furthermore, the as-obtained NaErF4@NaLuF4 UCNPs showed effective and applicable performance for upconversion luminescence (UCL) imaging, X-ray computed tomography (CT), and high-field T-2 magnetic resonance imaging (MRI). This nanomaterial can serve as an excellent theranostic agent for multimodality imaging and image-guided therapy.
Keyword	excitation-energy in-vitro nanoparticles luminescence nanocrystals enhancement nanoprobes dynamics contrast surface Chemistry Science & Technology - Other Topics Materials Science Physics
DOI	10.1039/c8nr00446c
Indexed By	SCI ; EI
Citation statistics	Cited Times:16[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.ciomp.ac.cn/handle/181722/60897
Collection	中国科学院长春光学精密机械与物理研究所
Recommended Citation GB/T 7714	Li, Q. Q.,Li, X. D.,Zhang, L.,et al. An 800 nm driven NaErF4@NaLuF4 upconversion platform for multimodality imaging and photodynamic therapy[J]. Nanoscale,2018,10(26):12356-12363.
APA	Li, Q. Q..,Li, X. D..,Zhang, L..,Zuo, J..,Zhang, Y. L..,...&Kong, X. G..(2018).An 800 nm driven NaErF4@NaLuF4 upconversion platform for multimodality imaging and photodynamic therapy.Nanoscale,10(26),12356-12363.
MLA	Li, Q. Q.,et al."An 800 nm driven NaErF4@NaLuF4 upconversion platform for multimodality imaging and photodynamic therapy".Nanoscale 10.26(2018):12356-12363.

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中国科学院长春光学精密机械与物理研究所