Therapeutic effect of chitosan on CCl4-induced hepatic fibrosis in rats

doi:10.3892/mmr.2018.9343

CIOMP OpenIR

	Therapeutic effect of chitosan on CCl4-induced hepatic fibrosis in rats
	Wang, Z. F.; Wang, M. Y.; Yu, D. H.; Zhao, Y.; Xu, H. M.; Zhong, S.; Sun, W. Y.; He, Y. F.; Niu, J. Q.; Gao, P. J.; Li, H. J.
	2018
发表期刊	Molecular Medicine Reports
ISSN	1791-2997
卷号	18 期号:3 页码:3211-3218
摘要	Chitosan is a linear polysaccharide that is made by treating the chitin shells of shrimp and crustaceans with an alkaline substance, for example sodium hydroxide. Due to its unique physical and chemical properties, chitosan has a wide range of applications in the medical field. Currently, there are no effective treatments for liver fibrosis; therefore, the aim of the present study was to investigate the therapeutic effect of chitosan in a CCl4-induced hepatic fibrosis (HF) rat model. The serum levels of aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) were measured by ELISA. Collagen (COL) 3 and alpha-smooth muscle actin (SMA) expression levels in the rat liver were detected by reverse transcription-semiquantitative polymerase chain reaction and western blotting, respectively. The results demonstrated that treatment with chitosan significantly improved HF, by decreasing the serum levels of AST, ALT, and ALP; improving liver histology; and decreasing the expression levels of COL3 and alpha-SMA. Chitosan may offer an alternative approach for the clinical treatment of HF.
关键词	hepatic fibrosis chitosan alpha-smooth muscle actin collagen 3 induced liver fibrosis acid phenethyl ester oxidative stress stellate cells drug-delivery derivatives activation mice injury Oncology Research & Experimental Medicine
DOI	10.3892/mmr.2018.9343
收录类别	SCI
引用统计
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/60834
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	Wang, Z. F.,Wang, M. Y.,Yu, D. H.,et al. Therapeutic effect of chitosan on CCl4-induced hepatic fibrosis in rats[J]. Molecular Medicine Reports,2018,18(3):3211-3218.
APA	Wang, Z. F..,Wang, M. Y..,Yu, D. H..,Zhao, Y..,Xu, H. M..,...&Li, H. J..(2018).Therapeutic effect of chitosan on CCl4-induced hepatic fibrosis in rats.Molecular Medicine Reports,18(3),3211-3218.
MLA	Wang, Z. F.,et al."Therapeutic effect of chitosan on CCl4-induced hepatic fibrosis in rats".Molecular Medicine Reports 18.3(2018):3211-3218.

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