Near Infrared Light Sensitive Ultraviolet-Blue Nanophotoswitch for Imaging-Guided Off-On Therapy

doi:10.1021/acsnano.7b07393

CIOMP OpenIR

	Near Infrared Light Sensitive Ultraviolet-Blue Nanophotoswitch for Imaging-Guided Off-On Therapy
	Zuo, J.; Tu, L. P.; Li, Q. Q.; Feng, Y. S.; Que, I.; Zhang, Y. L.; Liu, X. M.; Xue, B.; Cruz, L. J.; Chang, Y. L.; Zhang, H.; Kong, X. G.
	2018
发表期刊	Acs Nano
ISSN	1936-0851
卷号	12 期号:4 页码:3217-3225
摘要	Photoswitchable materials are important in broad applications. Recently appeared inorganic photoswitchable upconversion nanoparticles (PUCNPs) become a competitive candidate to surmount the widespread issue of the organic counterparts-photobleaching. However, current PUCNPs follow solely Yb3+/Nd3+ cosensitizing mode, which results in complex multilayer doping patterns and imperfectness of switching in UV-blue region. In this work, we have adopted a new strategy to construct Nd3+ free PUCNPs-NaErF4@NaYF4@ NaYbF4:0.5%Tm@NaYF4. These PUCNPs demonstrate the superior property of photoswitching. A prominent UV-blue emission from Tm3+ is turned on upon 980 nm excitation, which can be completely turned off by 800 nm light. The quasi monochromatic red upconversion emission upon 800 nm excitation-a distinct feature of undoping NaErF4 upconversion system-endows the PUCNPs with promising image-guided photoinduced "off-on" therapy in biomedicine. As a proof-of-concept we have demonstrated the imaging-guided photodynamic therapy (PDT) of cancer, where 800 nm excitation turns off the UV-blue emission and leaves the emission at 660 nm for imaging. Once the tumor site is targeted, excitation switching to 980 nm results in UV-blue emission and the red emission. The former is used to induce PDT, whereas the latter is to monitor the therapeutic process. Our study implies that this upconversion photoswitching material is suitable for real-time imaging and image-guided therapy under temporal and spatial control.
关键词	photoswitch upconversion photodynamic therapy imaging nanoparticle up-conversion nanoparticles photodynamic therapy excitation-energy nanocrystals luminescence fluorescence molecules migration dynamics probes Chemistry Science & Technology - Other Topics Materials Science
DOI	10.1021/acsnano.7b07393
收录类别	SCI
引用统计	被引频次：107[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/60733
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	Zuo, J.,Tu, L. P.,Li, Q. Q.,et al. Near Infrared Light Sensitive Ultraviolet-Blue Nanophotoswitch for Imaging-Guided Off-On Therapy[J]. Acs Nano,2018,12(4):3217-3225.
APA	Zuo, J..,Tu, L. P..,Li, Q. Q..,Feng, Y. S..,Que, I..,...&Kong, X. G..(2018).Near Infrared Light Sensitive Ultraviolet-Blue Nanophotoswitch for Imaging-Guided Off-On Therapy.Acs Nano,12(4),3217-3225.
MLA	Zuo, J.,et al."Near Infrared Light Sensitive Ultraviolet-Blue Nanophotoswitch for Imaging-Guided Off-On Therapy".Acs Nano 12.4(2018):3217-3225.

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