In vivo theranostics with near-infrared-emitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration

doi:10.1038/s41377-018-0090-1

CIOMP OpenIR

	In vivo theranostics with near-infrared-emitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration
	Bao, Xin; Yuan, Ye; Chen, Jingqin; Zhang, Bohan; Li, Di; Zhou, Ding; Jing, Pengtao; Xu, Guiying; Wang, Yingli; Hola, Kateina; Shen, Dezhen; Wu, Changfeng; Song, Liang; Liu, Chengbo; Zboil, Radek; Qu, Songnan
	2018
发表期刊	Bao et al. Light: Science & Applications
ISSN	20955545
卷号	7 期号:1
摘要	Carbon dots that exhibit near-infrared fluorescence (NIR CDs) are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents. Despite progress in the synthesis of NIR CDs, there remains a key obstacle to using them as an in vivo theranostic agent. This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy (PTT) in mouse models (conversion efficiency of 59%) and can be readily visualized by photoluminescence and photoacoustic imaging. The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting. Contrary to all other nanomaterials that have been tested in biomedicine, they are excreted through the bodys renal filtration system. Moreover, after intravenous injection, NIR CDs are accumulated in tumor tissue via passive targeting, without any active species such as antibodies. Due to their accumulation in tumor tissue without the need for intratumor injection, high photothermal conversion, excellent optical and photoacoustic imaging performance, and renal excretion, the developed CDs are suitable for transfer to clinical biomedical practice. 2018, The Author(s).
关键词	Infrared devices Carbon Medical applications Nanostructured materials Photoacoustic effect Photoluminescence Tumors
DOI	10.1038/s41377-018-0090-1
收录类别	EI
引用统计
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/60701
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	Bao, Xin,Yuan, Ye,Chen, Jingqin,等. In vivo theranostics with near-infrared-emitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration[J]. Bao et al. Light: Science & Applications,2018,7(1).
APA	Bao, Xin.,Yuan, Ye.,Chen, Jingqin.,Zhang, Bohan.,Li, Di.,...&Qu, Songnan.(2018).In vivo theranostics with near-infrared-emitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration.Bao et al. Light: Science & Applications,7(1).
MLA	Bao, Xin,et al."In vivo theranostics with near-infrared-emitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration".Bao et al. Light: Science & Applications 7.1(2018).

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